Publications by authors named "Ravi Kumar Eslavath"
Hypoxia inducible factor (HIF)-1α, a subunit of HIF transcription factor, regulates cellular response to hypoxia. In normoxic conditions, it is hydroxylated by prolyl hydroxylase (PHD)-2 and targeted for proteosomal degradation. Drugs which inhibit PHD-2 have implications in conditions arising from insufficient blood supply.
View Article and Find Full Text PDFThe compound N-(2-hydroxybenzylidene)-1-ethyl-1, 4-dihydro-7-methyl-4-oxo-1, 8 naphthyridine-3-carbohydrazide (LH) and its Cu (II), Co (II) and Zn (II) complexes were synthesized and characterized. The absorption spectral titrations and competitive DNA binding studies depicted those complexes of title compound bind to CT-DNA through intercalation. Interestingly [Cu (II)-(L2)] showed relatively high binding constant value (6.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on developing and analyzing metal complexes (Cu (II), Cd (II), Ce (IV), and Zr (IV)) using a specific imine derivative, including their DNA interaction, photo-cleavage, and antioxidant properties.
- Characterization techniques such as EDX, IR, and NMR were used to confirm the synthesis of these complexes, while spectrophotometric methods assessed their reactivity and interactions with DNA, revealing a tendency to intercalate.
- The results indicated that these metal complexes exhibit significant antibacterial activity and dose-dependent cytotoxicity in cell lines, suggesting potential for new therapeutic drug development, bolstered by molecular modeling and docking studies to understand receptor interactions.