A risk index for advanced neoplasia on the second surveillance colonoscopy in patients with previous adenomatous polyps.

Background: Predicting the risk of advanced colorectal neoplasia on the second surveillance colonoscopy could help tailor surveillance.

Objective: To derive and validate a risk index for advanced neoplasia on the second surveillance colonoscopy.

Design: Retrospective cohort.

Yield of the second surveillance colonoscopy based on the results of the index and first surveillance colonoscopies.

Background And Study Aims: The risk of advanced colorectal neoplasia (ACN) after the first surveillance colonoscopy is not well quantified. The aim of the current study was to quantify the risk of ACN on the second surveillance colonoscopy based on previous colonoscopic findings.

Patients And Methods: This was a single-site study of patients with index adenomas who underwent two surveillance colonoscopies.

Oxidative stress in chronic liver disease: relationship between peripheral and hepatic measurements.

Introduction: Oxidative stress plays an important role in the pathogenesis of many liver diseases. Investigators often measure markers of oxidative stress in peripheral veins as a reflection of hepatic oxidative stress as it is not always feasible to measure oxidative stress in liver tissue. However, it is unknown whether markers of oxidative stress measured from peripheral sites accurately reflect hepatic tissue oxidative stress.

Polyethylene glycol vs. sodium phosphate for bowel preparation: a treatment arm meta-analysis of randomized controlled trials.

Background: Results of meta-analyses of randomized trials comparing PEG and NaP are inconsistent and have not included trials comparing either or both preps to less traditional ones.

Aim: To perform a meta-analysis by treatment arm.

Methods: Using MEDLINE and EMBASE, we identified English-language trials published from 1990 to 2008 that included PEG and/or NaP, and aggregated them by treatment arm into: 4 liter (L) PEG; 2 L PEG; split-dose PEG; two 45 ml doses of NaP +/- adjunctive medication; and NaP tablets.

Drug-induced QT prolongation in cirrhotic patients with transjugular intrahepatic portosystemic shunt.

Goals And Background: Nearly 40% of cytochrome P450 3A (CYP3A) activity is located in the small intestine. An earlier study has shown that cirrhotics with transjugular intrahepatic portosystemic shunts (TIPS) have diminished intestinal CYP3A activity. We hypothesized that oral CYP3A substrates known to prolong QT interval may cause further prolongation of the QT interval in cirrhotic patients with TIPS.

Generalizability of the nonalcoholic steatohepatitis Clinical Research Network histologic scoring system for nonalcoholic fatty liver disease.

Goals And Background: The recently developed histologic scoring system for nonalcoholic fatty liver disease (NAFLD) by the nonalcoholic steatohepatitis (NASH) Clinical Research Network (CRN) is becoming increasingly popular. However, its generalizability to a community setting has not been evaluated. We conducted a study to compare a community general pathologist to an expert hepatopathologist in assessing NAFLD using the NASH CRN scoring system.