Publications by authors named "Raven S Bell"
Background: Prostanoids are a family of lipid mediators formed from arachidonic acid by cyclooxygenase enzymes and serve as biomarkers of vascular function. Prostanoid production may be different in males and females indicating that different therapeutic approaches may be required during disease.
Objectives: We examined sex-dependent differences in COX-related metabolites in genetically modified mice that produce a cyclooxygenase-2 (COX2) enzyme containing a tyrosine 385 to phenylalanine (Y385F) mutation.
Article Synopsis
- A fluoroquinophenoxazine compound (FP-11g) shows effective inhibition of bacterial topoisomerase I and displays strong antituberculosis activity with a minimal inhibitory concentration (MIC) of 2.5 μM against Mycobacterium tuberculosis.
- The compound exhibited bactericidal properties against Mycobacterium smegmatis, resulting in significant reductions in viable bacterial counts after incubation and also demonstrated some efficacy against Mycobacterium abscessus.
- Resistance mechanisms were studied by isolating mutants of M. smegmatis through whole-genome sequencing, revealing mutations that may influence the compound's uptake, while highlighting that FP-11g's interactions with DNA are essential but not solely responsible for its antimicrobial effects