Novel Biomarkers of Health and Degeneration in Human Intervertebral Discs: In-depth Proteomic Analysis of Collagen Framework of Fetal, Healthy, Scoliotic, Degenerate, and Herniated Discs.

Study Design: Profiling proteins expressed in the nucleus pulposus (NP) of intervertebral discs (IVDs) in five different biological states.

Purpose: To evaluate the molecular complexity of the collagen (COL) framework and its role in the health and disease of human IVDs.

Overview Of Literature: Changes in COL composition have been linked to degenerative disk disease (DDD).

Prevalence, Patterns, and Genetic Association Analysis of Modic Vertebral Endplate Changes.

Study Design: A prospective genetic association study.

Purpose: The etiology of Modic changes (MCs) is unclear. Recently, the role of genetic factors in the etiology of MCs has been evaluated.

How Reliable Are the Reported Genetic Associations in Disc Degeneration?: The Influence of Phenotypes, Age, Population Size, and Inclusion Sequence in 809 Patients.

Study Design: Prospective genetic association study.

Objective: The aim of this study was to document the variations in the genetic associations, when different magnetic resonance imaging (MRI) phenotypes, age stratification, cohort size, and sequence of cohort inclusion are varied in the same study population.

Summary Of Background Data: Genetic associations with disc degeneration have shown high inconsistency, generally attributed to hereditary factors and ethnic variations.

Genetic susceptibility of lumbar degenerative disc disease in young Indian adults.

Purpose: Although the exact mechanisms that lead to degenerative disc disease (DDD) are not well understood, a significant genetic influence has been found. Focusing on DDD that occurs in young adults can be valuable in determining the exact role of genetic predisposition to DDD.

Methods: Patients (<40 years) with lumbar disc degeneration were evaluated with MRI imaging (1.

MAGICdb - Mango Genetic stocks Identification and Characterisation database.

MAGICdb is a unique database that integrates the morphological, fruit quality and the marker data of most popular and widely cultivated commercially important mango cultivars. The main objective of MAGICdb is to provide the end users with an integrated dataset of each mango variety cultivated widely in Tamil Nadu. MAGICdb structure is categorized in to three domains namely Morphological Data Search, Fruit Quality Search and Marker Search which in further contains details on Tree Character, Bearing Habit, Season of fruiting, Number of inflorescence/Sq.

Phenotype variations affect genetic association studies of degenerative disc disease: conclusions of analysis of genetic association of 58 single nucleotide polymorphisms with highly specific phenotypes for disc degeneration in 332 subjects.

Background Context: Although the influence of genetics on the process of disc degeneration is well recognized, in recently published studies, there is a wide variation in the race and selection criteria for such study populations. More importantly, the radiographic features of disc degeneration that are selected to represent the disc degeneration phenotype are variable in these studies. The study presented here evaluates the association between single nucleotide polymorphisms (SNPs) of candidate genes and three distinct radiographic features that can be defined as the degenerative disc disease (DDD) phenotype.