Inadvertent higher rate atrial pacing after dual chamber pacemaker implantation - What is the underlying mechanism?

Unexplained change in parameters, despite good lead positions or odd ECG patterns following implant should lead to suspicion of lead swap, amongst other possibilities. An easy way to confirm this is by paying careful attention to device EGMs and recording the ECG by switching off one channel, and pacing single channel (in either AAI or VVI mode).

Changes in Smoking Patterns in Turkey Before and After the Ban on Loose Cigarettes: An Ecological Perspective From Global Tobacco Surveillance Data.

Introduction: Loose or individual cigarettes sold without packaging pose a unique challenge for tobacco control, which is the leading cause of premature and preventable mortality worldwide. This study aims to assess the changes in smoking patterns following the ban on loose cigarettes in 2008 in Turkey.

Method: Gender-stratified trend analysis of smoking patterns before and after the ban on loose cigarettes was done using the Global Tobacco Surveillance data (adults: Global Adult Tobacco Survey (GATS) 2008, 2012, and 2016; youth: Global Youth Tobacco Survey (GYTS) 2003, 2005, 2009, 2012, and 2017) from Turkey.

Use of strain imaging to detect subtle myocardial involvement in post COVID-19 patients: An Indian perspective.

Background: The study assessed Global longitudinal strain imaging (GLS) to detect subtle myocardial dysfunction among patients clinically recovered from COVID-19.

Methods: All patients (n = 101 76 % males, mean age 55.45 ± 11.

RAdiation Dose Attenuation using RADPAD in CATH lab for primary and secondary operators - RADAR-CATH STUDY.

Background: Radiation injury is an important concern for interventional cardiologists and needs to be addressed. RADPAD is a radiation protection drape that has been shown to reduce the radiation exposure of the primary operator (PO). While Indian data on radiation exposure of the PO in the cath lab are scarce, the exposure of the secondary operator (SO) is even less well studied.

Critical appraisal of YouTube videos regarding peri-implant diseases and conditions: A cross-sectional analysis.

Purpose: To critically appraise the quality and reliability of YouTube videos regarding peri-implant diseases and conditions as a source of information for patients, students, and young clinicians.

Materials And Methods: In March 2023, electronic searches were performed on YouTube website to identify videos related to peri-implant diseases and conditions. We considered only the relevant 250 English-language videos with durations between 3 and 30 min for final analyses.

Critical evaluation of YouTube videos regarding the all-on-4 dental implant treatment concept: A content-quality analysis.

Statement Of Problem: Rehabilitation of complete edentulous arches by using the all-on-4 dental implant treatment concept is a well-established procedure. Considering the popularity of YouTube as a source for health-related information, a thorough investigation of the content-quality and reliability of videos regarding the all-on-4 concept is lacking.

Purpose: The purpose of this cross-sectional analysis was to critically appraise the content-quality and reliability of YouTube videos regarding the all-on-4 dental implant treatment concept as a source of information for patients, students, and dentists.

An Unusual Hemodynamic Pressure Trace Mimicking Aortic Stenosis: A Decepti "Con".

We report an abnormal hemodynamic pressure tracing taken during pullback from the left ventricle. This report emphasizes the careful observation of hemodynamic tracing relative to continuous electrocardiographic monitoring for identifying potentially pathological vascular phenomena that may have detrimental outcomes on the clinical management of the underlying condition.

Evidence of direct interaction between cisplatin and the caspase-cleaved prostate apoptosis response-4 tumor suppressor.

Prostate apoptosis response-4 (Par-4) tumor suppressor protein has gained attention as a potential therapeutic target owing to its unique ability to selectively induce apoptosis in cancer cells, sensitize them to chemotherapy and radiotherapy, and mitigate drug resistance. It has recently been reported that Par-4 interacts synergistically with cisplatin, a widely used anticancer drug. However, the mechanistic details underlying this relationship remain elusive.

A pilot study evaluating the role of ivabradine for rate control in patients with rheumatic atrial fibrillation.

Objectives: Ivabradine may have a role in rate control of atrial fibrillation (AF) due to effects on HCN channels in AV node. We studied role of Ivabradine in rate control of rheumatic AF.

Methods: 80 patients, rheumatic AF, HR > 100 bpm (age 47 ± 11 yrs, AF duration 6.

Enhancing the Conformational Stability of the cl-Par-4 Tumor Suppressor via Site-Directed Mutagenesis.

Intrinsically disordered proteins play important roles in cell signaling, and dysregulation of these proteins is associated with several diseases. Prostate apoptosis response-4 (Par-4), an approximately 40 kilodalton proapoptotic tumor suppressor, is a predominantly intrinsically disordered protein whose downregulation has been observed in various cancers. The caspase-cleaved fragment of Par-4 (cl-Par-4) is active and plays a role in tumor suppression by inhibiting cell survival pathways.

The unusual case of a Topsy-Turvy ECG with a pseudo-infarct pattern.

Unique electrocardiogram (ECG) patterns can be generated by inadvertent lead misplacements. The commonest of these is left arm-right arm (LA-RA) reversal leading to inverted lead I, right axis deviation and an upright aVR. Changes in placement of the neutral (right leg: RL) electrode with one of the LA or RA cables may produce more atypical patterns, which often mimic myocardial ischemia.

Structural Analysis of the cl-Par-4 Tumor Suppressor as a Function of Ionic Environment.

Prostate apoptosis response-4 (Par-4) is a proapoptotic tumor suppressor protein that has been linked to a large number of cancers. This 38 kilodalton (kDa) protein has been shown to be predominantly intrinsically disordered in vitro. In vivo, Par-4 is cleaved by caspase-3 at Asp-131 to generate the 25 kDa functionally active cleaved Par-4 protein (cl-Par-4) that inhibits NF-κB-mediated cell survival pathways and causes selective apoptosis in tumor cells.

Bioefficacy of Lemongrass and Tea Tree Essential Oils Against House Fly, .

Abstract: The management of house fly, has become immensely important to prevent epidemics of many detrimental diseases. In view of this objective, the present study demonstrates the efficacy of lemongrass (LG) and tea tree essential oils (TTEOs) against . The TTEO proved to be more lethal against larvae and adults of depicting an LC at 14.

Awareness regarding Menstrual Hygiene among Girl Students of a School in Chitwan.

Introduction: Adolescent girls often lack knowledge regarding reproductive health including menstruation which can be due to socio-cultural barriers in which they grow up. It is important to educate adolescents about issues related to menstruation so that they can safeguard themselves and hold implications for professionals involved in improvement of reproductive health. The main objective of the study was to find out awareness regarding menstrual hygiene among girl students of a school in Chitwan.

Prevalence and Indications of Cesarean Section in a Community Hospital of Western Region of Nepal.

Introduction: Cesarean section is one of the common obstetric procedures done when the childbirth is not anticipated to occur by the normal vaginal delivery. There has been increased rate of cesarean section globally as well as in our country in recent decades.

Methods: This descriptive cross-sectional study has been carried out by reviewing a year of data from maternity ward of Paschimanchal Community Hospital, Prithvi Chowk, Pokhara.

Awareness on Girl Child Abuse Among Mothers of A Selected Community.

Introduction: Girl Child Abuse is physically, emotionally, sexually abusing and neglecting the girl child by depriving her of universally accepted child rights. We aim to determine the awareness on girl child abuse among mothers so that necessary awareness programs could be recommended if found unsatisfactory.

Methods: A descriptive cross-sectional study was done in Sundarbazar municipality of Lamjung district among randomly selecting 288 mothers who participated voluntarily in face to face interview that used structured questionnaire from 27th March to 23rd April, 2016.

Dietary Practice among the Patients with End Stage Renal Disease undergoing Maintenance Haemodialysis.

Introduction: Several studies on the nutritional status of chronic kidney disease patients living on haemodialysis revealed high prevalence of malnutrition (18-94%). A hospital-based study in Nepal revealed 66.7% mild to moderately malnourished and National Kidney Center reported common protein-energy malnutrition problem among haemodialysis patients.

Electronic and thermoelectric properties of Zn and Se double substituted tetrahedrite.

The influence of Zn and Se double substitution on the electronic and thermoelectric properties of tetrahedrite was investigated in this study. The samples Cu11Zn1Sb4S13-xSex (x = 0.25, 0.

Lifetime Experience of Violence in Early Adulthood Female.

Introduction: Despite political commitment and a supportive legal and policy framework, violence against women remains a significant problem in Nepal. Nepal Demographic and Health Survey reported more than one in five women experience violence in lifetime. Three fourth of women who had experienced physical or sexual violence had not sought any help.

Comparison of Intrathecal Clonidine and Fentanyl as Adjuvant to Hyperbaric Bupivacaine in Subarachnoid Block for Lower Limb Orthopedic Surgery.

Background: Many studies are there using adjuvants such as clonidine and fentanyl with bupivacaine in the subarachnoid block for prolonging postoperative analgesia. However, literature is divided regarding the dosage and efficacy of both intrathecal adjuvants. Furthermore, these adjuvants have their own side effects.

Intestinal Worm Infestation and Anaemia in Pregnant Women.

Introduction: Severe Anaemia during pregnancy is an important contributor to maternal mortality, as well as to the low birth weight which is in turn an important risk factor for infant mortality. We aim to determine the prevalence of anaemia in the region amongst pregnant women and identify their problems and to easily provide them with the clinical services.

Methods: A community based cross sectional study done in PHCRC Chapagaun, Lalitpur from July 17,2011 to September 17,2011.

Wasp bite in a referral hospital in Nepal.

Background: Wasp bite is an important occupational hazard in Nepal. Almost 25% of the victims die. This study aimed to identify the demographics, clinical presentation, hospital course and outcome of wasp bite victims in a referral hospital in Nepal.

Prevalence of metabolic syndrome in chronic kidney disease: a hospital based cross-sectional study.

Background: The components of metabolic syndrome (MetS) are the established risk factors of chronic kidney disease (CKD). Therefore, MetS and interplay of its various components, have deleterious effects on patients with chronic kidney disease. The aims of our study was to find out the prevalence of MetS in chronic kidney disease patients and to find out the association of each component of MetS with chronic kidney disease.

Serum uric acid level in newly diagnosed essential hypertension in a Nepalese population: a hospital based cross sectional study.

Objective: To develop the missing link between hyperuricemia and hypertension.

Methods: The study was conducted in Department of Biochemistry in collaboration with Nephrology Unit of Internal Medicine Department. Hypertension was defined according to blood pressure readings by definitions of the Seventh Report of the Joint National Committee.