Identification of novel inhibitors for trigger factor (TF) of : an investigation.

Trigger factor, as a chaperone protein, is required for survival of Mycobacterium tuberculosis () in a stressed environment. This protein interacts with various partners in both the pre- and the post-translation processes, yet the crystal structures of the trigger factor remain unresolved. In this study, we developed a homology model of trigger factor to facilitate the discovery and design of inhibitors.