Publications by authors named "Raunak Rao"
Background: The management of combined anterior cruciate ligament (ACL) and medial collateral ligament (MCL) injuries remains contentious. Clinical outcomes of surgical, conservative, and combined approaches have been described in a range of prospective and retrospective studies. The aim of the current systematic review was to evaluate these outcomes and assess the study methodologies.
View Article and Find Full Text PDFBackground And Aims: Animal models of human disease are a key component of translational hepatology research, yet there is no consensus on which model is optimal for NAFLD.
Approach And Results: We generated a database of 3,920 rodent models of NAFLD. Study designs were highly heterogeneous, and therefore, few models had been cited more than once.
Article Synopsis
- - Medication nonadherence in hypertension patients is a key factor, with a study showing a 40.3% overall rate of nonadherence, including complete nonadherence in 14.4% of cases and partial nonadherence in 25.9% of patients.
- - Women were found to be 3.3 times more likely to be nonadherent, and as the number of prescribed antihypertensive medications increased, so did the likelihood of nonadherence, particularly in patients prescribed 6 or more medications.
- - Identifying and understanding the predictors of nonadherence, such as sex and the number of medications, is critical for effectively managing uncontrolled hypertension.
Two Cases of Severe Hypertension in JAK2 Mutation-Positive Myeloproliferative Neoplasms.
Case Rep Vasc Med
November 2020
Background: Myeloproliferative neoplasms are a heterogeneous group of disorders resulting from the abnormal proliferation of one or more terminal myeloid cells-established complications include thrombosis and haemorrhagic events; however, there is limited evidence to suggest an association with arterial hypertension. Herein, we report two independent cases of severe hypertension in JAK2 mutation-positive myeloproliferative neoplasms. .
View Article and Find Full Text PDFThe classical drug development pipeline necessitates studies using animal models of human disease to gauge future efficacy in humans, however there is a low conversion rate from success in animals to humans. Non-alcoholic fatty liver disease (NAFLD) is a complex chronic disease without any established therapies and a major field of animal research. We performed a meta-analysis with meta-regression of 603 interventional rodent studies (10,364 animals) in NAFLD to assess which variables influenced treatment response.
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