Publications by authors named "Raul Piseaux"
The mitochondrial electron transport chain (ETC) is necessary for tumour growth and its inhibition has demonstrated anti-tumour efficacy in combination with targeted therapies. Furthermore, human brain and lung tumours display robust glucose oxidation by mitochondria. However, it is unclear why a functional ETC is necessary for tumour growth in vivo.
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- Researchers studied how different strains of a bacteria compete in the lungs, especially for causing pneumonia in hospitals.
- They created a special method called "StrainSeq" to see how 10 different strains behaved in mice with pneumonia.
- One strain called KPPR1 was very dominant in causing disease early on, but other strains could take over when KPPR1 was not present, suggesting some strains are better at surviving in the lungs than others.
Rationale: Alveolar epithelial cell (AEC) injury and mitochondrial dysfunction are important in the development of lung fibrosis. Our group has shown that in the asbestos exposed lung, the generation of mitochondrial reactive oxygen species (ROS) in AEC mediate mitochondrial DNA (mtDNA) damage and apoptosis which are necessary for lung fibrosis. These data suggest that mitochondrial-targeted antioxidants should ameliorate asbestos-induced lung.
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