Publications by authors named "Raul Parra-Garces"
Article Synopsis
- Cinitapride is a gastrointestinal drug used for functional dyspepsia and gastroesophageal reflux disease, and this study investigates the effects of genetic variants on its pharmacokinetics and safety.
- Researchers genotyped healthy volunteers for variants in 19 pharmacogenes, identifying that carriers of the CYP2C8*3 allele had significantly reduced drug exposure, while *4 allele carriers had increased exposure, although not statistically significant.
- The study helps define pharmacogenetic phenotypes for metabolizers of cinitapride, emphasizing the need for further research to fully understand the implications for other drugs metabolized by CYP2C8.
-Adverse drug reactions (ADRs) are a public health issue, due to their great impact on morbidity, mortality, and economic cost. The use of automatized laboratory alerts could simplify greatly its detection. -We aimed to evaluate the performance of a laboratory alerts system as a method for detecting ADRs, using hyponatremia and rhabdomyolysis as case studies.
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