Maritornes and genetics.

Maritornes is a female character created by Cervantes for . She appears in several chapters of part one and takes on a greater role in chapters XVI and XLIII. In her first appearance in chapter XVI, Cervantes describes Maritornes as having physical signs compatible with a genetic disorder.

Tamoxifen vs. non-tamoxifen treatment for advanced melanoma: a meta-analysis.

Although tamoxifen (TAM) is routinely used in advanced melanoma, it is still uncertain whether evidence exists to support this practice. This review assesses the benefits and harms of systemic therapy with TAM vs. without TAM on response and mortality in patients with advanced melanoma.

Control of Moderate-to-Severe Plaque Psoriasis with Efalizumab: 24-Week, Open-Label, Phase IIIb/IV Latin American Study Results.

INTRODUCTION: Psoriasis is a debilitating, chronic inflammatory systemic disease affecting around 2% of the South American population. Biological therapies offer the possibility of long-term therapy with improved safety and efficacy. METHODS: We conducted a multicentre, open-label, single-arm, Phase IIIb/IV study of adult patients (18-75 years) with moderate-to-severe plaque psoriasis who were candidates for systemic therapy or phototherapy.