Synthesis of 3,3-Disubstituted Allyl Isoindolinones via Pd-Catalyzed Decarboxylative Allylic Alkylation.

Herein, we report a mild palladium-catalyzed decarboxylative allylic alkylation of allyl ester-substituted isoindolinone substrates to afford a variety of 3,3-disubstituted isoindolinone derivatives. The decarboxylative coupling reaction tolerates a range of functional groups, including ketones and alkenyl halides, and does not require protection of the isoindolinone nitrogen. Additionally, the reaction was found to proceed in near-quantitative yield for most substrates evaluated.

Preschool Aggression and Victimization: A Short-Term Longitudinal Analysis of the Immediate Social Environment.

Introduction: Preschool aggression, a significant concern, requires an in-depth examination beyond individual factors. This study explored the link between individual characteristics, immediate social environment variables, and the likelihood of preschoolers being nominated as aggressors or victims. The novelty of the study lies in its comprehensive longitudinal examination, using a multi-informant approach, of how family dynamics, peer relations, teacher-child interactions, and community factors are related to preschool aggression within the context of Bronfenbrenner's ecological system theory.

Attachment insecurity and breadcrumbing engagement in young adults: a cross-sectional, cross-country study in India and Spain.

Background: Breadcrumbing, defined as the act of sending out flirtatious, but non-committal text messages to lure a sexual/romantic partner without expending much effort, has gained attention in popular culture and the media due to its relevance to contemporary dating dynamics. However, there is lack of evidence of the association between attachment insecurity and breadcrumbing This study aims to uncover the potential relationship between breadcrumbing engagement and attachment insecurity among Indian and Spanish young adults.

Methods: Data were collected through an anonymous online survey answered by 334 adults in India and by 348 adults in Spain aged between 18 and 40 years old.

Parenting Styles and Self-Esteem in Adolescent Cybervictims and Cyberaggressors: Self-Esteem as a Mediator Variable.

Background: Family relationships and self-esteem are relevant variables into the understanding of cyberbullying. However, little is known about the mediating role of self-esteem in the connections between cyberbullying and parenting. The study had two goals: (1) to analyze the relation between being a cybervictim and/or cyberaggressor and self-esteem, parents' acceptance/coercion, and parenting styles and (2) to explore whether self-esteem is a mediator in the relationship between parents' acceptance/coercion and being a cybervictim/cyberaggressor.

Families, Parenting and Aggressive Preschoolers: A Scoping Review of Studies Examining Family Variables Related to Preschool Aggression.

Background: A growing body of research has shown that children behave aggressively from an early age. In recent decades, such behaviour has become a focus of scientific interest, not only because of the adverse consequences of these interactions, but also because high levels of aggression, especially at an early age, may be a risk factor for the use of other forms of aggression, such as bullying, later on during their development. These behaviours are related not only to individual characteristics, but also to peer relationships, teacher behaviours, school variables, family factors and cultural influences.

Associations between Adverse Childhood Experiences within the Family Context and In-Person and Online Dating Violence in Adulthood: A Scoping Review.

: Adverse childhood experiences (ACEs) are a common pathway to risky behaviour, violence or re-victimisation, disability, illness, and premature mortality and, as such, may be associated with victimisation and perpetration of dating violence not only in adolescence but also in adulthood. A scoping review was performed in accordance with PRISMA guidelines. Four databases (Web of Science, Scopus, PubMed, and PsycINFO) were used to search for studies published between 2000 and 2021 that analysed the relationship between adverse childhood experiences within the family context and the perpetration or victimisation of dating violence in adulthood.

Decarboxylative Allylic Alkylation of Phthalides: Stabilized Benzylic Nucleophiles for sp-sp Coupling.

A new family of stabilized benzylic nucleophiles for the palladium-catalyzed decarboxylative allylic alkylation reaction has been developed. Allyl esters derived from 3-carboxyphthalides were found to undergo palladium-catalyzed deallylation and decarboxylation under mild reaction conditions, a process facilitated by the formation of a stabilized aromatic anion. The regioselective allylic coupling of this intermediate afforded a variety of functionalized phthalides in 73-96% yields.

Enantioselective Synthesis of (-)-10-Hydroxyacutuminine.

An enantioselective synthesis of (-)-10-hydroxyacutuminine is reported. Central to our strategy is a photochemical [2+2] cycloaddition that forges two of the quaternary stereocenters present in the acutumine alkaloids. A subsequent retro-aldol/Dieckmann sequence furnishes the spirocyclic cyclopentenone.

Relationship between Socio-Emotional Competencies and the Overlap of Bullying and Cyberbullying Behaviors in Primary School Students.

Digital life forms part of daily reality for young people. For this reason, traditional bullying in school has been reproduced in the online environment, resulting in an overlap of off- and online bullying. Research on socio-emotional competencies and bullying is revealing interesting results among students in secondary schools.

Psychological Correlates of Ghosting and Breadcrumbing Experiences: A Preliminary Study among Adults.

The present study aimed to examine differences in three psychological constructs (satisfaction with life, loneliness, and helplessness) among adults experiencing ghosting and breadcrumbing. A sample of 626 adults (303 males and 323 females), aged from 18 to 40 years, completed an online survey asking to indicate whether someone they considered a dating partner had ghosted or breadcrumbed them in the last year and to complete three different scales regarding satisfaction with life, loneliness, and helplessness. The results showed than those participants who had indicated experiencing breadcrumbing or the combined forms (both breadcrumbing and ghosting) reported less satisfaction with life, and more helplessness and self-perceived loneliness.

Relations among Poly-Bullying Victimization, Subjective Well-Being and Resilience in a Sample of Late Adolescents.

The present study examined the relations among poly-bullying victimization (experiencing multiple forms of peer bullying), resilience and subjective well-being. This study specifically examined late adolescents' resilience as a moderator of the relation between poly-bullying victimization and subjective well-being. In a region of central Spain, 1430 undergraduate students (64% females, 36% males), aged between 18 and 22 years, completed three self-reported measures, including bullying victimization experiences, self-reported subjective well-being and resilience.

The Role of Social-Interpersonal and Cognitive-Individual Factors in Cyber Dating Victimization and Perpetration: Comparing the Direct, Control, and Combined Forms of Abuse.

The present study examined the relationship linking social-interpersonal factors (interpersonal dependency, social support, social skills), cognitive-individual factors (planning behavior and goal efficacy), and different victimization and perpetration forms of cyber dating abuse (direct abuse, control abuse, and the combination of both abuse types). The responses of 1,657 Spanish university students were analyzed (62.1% females, 37.

Associations between Feminine Gender Norms and Cyber Dating Abuse in Female Adults.

Gender norms and the co-occurrence of perpetration and victimization behaviors have been examined as key factors of female dating violence in offline contexts. However, these relationships have not been analyzed in digital environments. This is why the present study had a twofold objective: (1) exploring the co-occurrence nature of cyber dating abuse by examining to what extent victimization and perpetration overlap; (2) examining the associations between conformity to feminine gender norms and cyber dating abuse among female adults who are perpetrators or victims.

Health Contributing Factors in Higher Education Students: The Importance of Family and Friends.

The aim of this study was to determine well-being and its relationship to social support from friends and family communication in university students. A cross-sectional study was conducted with 1679 university students aged 18⁻25 years from four universities in Spain. Logistical regression models were tested ( < 0.

Effectiveness of low-frequency electrical stimulation in proprioceptive neuromuscular facilitation techniques in healthy males: a randomized controlled trial.

Background: Hamstring muscle injuries are common in the sports field, with lack of hamstring flexibility being a risk factor. Stretching the hamstring muscles is an important part of the training and rehabilitation programs used to prevent or treat injury and improve performance. We aim to compare the immediate and follow-up effect on hamstring muscle flexibility between 2 different stretching protocols, proprioceptive neuromuscular facilitation (PNF) stretching and PNF stretching combined with electrostimulation.

Negative Peer Relationships on Piracy Behavior: A Cross-Sectional Study of the Associations between Cyberbullying Involvement and Digital Piracy.

The present study examines the relationship between different roles in cyberbullying behaviors (cyberbullies, cybervictims, cyberbullies-victims, and uninvolved) and self-reported digital piracy. In a region of central Spain, 643 (49.3% females, 50.

Tuberculosis among indigenous municipalities in Mexico: analysis of case notification and treatment outcomes between 2009 and 2013.

Objective To assess trends in 1) tuberculosis (TB) case notification by year and 2) cumulative treatment outcomes (stratified by type of TB) in relation to the proportion of indigenous population in municipalities in a countrywide study in Mexico for the period 2009-2013. Methods This ecological operational research study used municipality data for the five-year study period. As no single identifier variable existed for indigenous persons, municipalities were categorized into one of three groups based on the proportion of their indigenous population (< 25% ("low"), ≥ 25% to < 50% ("medium"), and ≥ 50% ("high")).

A Novel Destabilizing Domain Based on a Small-Molecule Dependent Fluorophore.

Tools that can directly regulate the activity of any protein-of-interest are valuable in the study of complex biological processes. Herein, we describe the development of a novel protein domain that exhibits small molecule-dependent stability and fluorescence based on the bilirubin-inducible fluorescent protein, UnaG. When genetically fused to any protein-of-interest, this fluorescent destabilizing domain (FDD) confers its instability to the entire fusion protein, facilitating the rapid degradation of the fusion.

Chemical biology strategies for posttranslational control of protein function.

A common strategy to understand a biological system is to selectively perturb it and observe its response. Although technologies now exist to manipulate cellular systems at the genetic and transcript level, the direct manipulation of functions at the protein level can offer significant advantages in precision, speed, and reversibility. Combining the specificity of genetic manipulation and the spatiotemporal resolution of light- and small molecule-based approaches now allows exquisite control over biological systems to subtly perturb a system of interest in vitro and in vivo.

Rapid construction of the aza-propellane core of acutumine via a photochemical [2 + 2] cycloaddition reaction.

Synthetic efforts toward the chlorinated aza-propellane alkaloid acutumine (1) are described. The key vicinal quaternary centers were constructed by a photochemical [2 + 2] cycloaddition reaction of a furanyl-tetrahydroindolone. Dihydroxylation of the [2 + 2] product enabled a tandem retro-aldol/intramolecular ketalization reaction, which revealed the aza-propellane core of 1 while generating an unusual, caged, pentacyclic hemiketal product.

The effects of two soft drinks on bond strength, bracket microleakage, and adhesive remnant on intact and sealed enamel.

The purpose of this study was to evaluate the effects of Coca-Cola and Schweppes Limón on bond strength, adhesive remnant, and microleakage beneath brackets. One hundred and twenty upper central incisor brackets were bonded to bovine incisors and divided into three groups: (1) Control, (2) Coca-Cola, and (3) Schweppes Limón. The teeth were submerged in the drinks three times a day for 15 minutes over a 15 day period.

Regio- and Stereoselective Direct Cross-Coupling of Aromatic Imines with Allenic Alcohols.

We describe a titanium-mediated reaction for the convergent coupling of allenic alcohols with aromatic imines. Overall, the bond formation occurs at the central carbon of the allene, proceeds with net allylic transposition, and provides substituted 1,3-dienes bearing allylic amine functionality in a regio- and stereoselective fashion.

Effect of surface treatments on the bond strength of brackets bonded with a compomer.

Purpose: To evaluate the effectiveness of the compomer Dyract AP for bonding brackets when conditioning the enamel with phosphoric acid and a non-rinsing conditioner (NRC), in comparison with a control group in which the resin orthodontic adhesive system Transbond XT was used.

Methods: The brackets were bonded to extracted premolars which were divided into three groups: (1) Acid/Transbond XT, (2) NRC/Dyract AP and (3) Acid/Dyract AP. Shear bond strength was measured with a universal testing machine.