Linking hepatitis C virus infection to pre-1994 blood transfusions in female patients.

Introduction: Most blood transfusions occur in female patients. The introduction of serologic screening practices by blood banks reduced the transfusion-related rate of infection with hepatitis C virus (HCV). In Mexico patients with pre-1994 transfusion history are at high risk of being detected with HCV infection.

Glutamate excitotoxicity activates the MAPK/ERK signaling pathway and induces the survival of rat hippocampal neurons in vivo.

Current knowledge concerning the molecular mechanisms of the cellular response to excitotoxic insults in neurodegenerative diseases is insufficient. Although glutamate (Glu) has been widely studied as the main excitatory neurotransmitter and principal excitotoxic agent, the neuroprotective response enacted by neurons is not yet completely understood. Some of the molecular participants have been revealed, but the signaling pathways involved in this protective response are just beginning to be identified.

Cerebral cholinergic neurotransmission in protein and tryptophan-restricted adult rats.

To evaluate the effects of protein and tryptophan restriction on cholinergic neurotransmission in terms of choline acetyltransferase (CAT) activity and its expression as well as muscarinic receptors number at cerebral cortex and hippocampus, Wistar rats were raised on a chronically protein and tryptophan restricted diets with 8% protein based on either Purina chow or corn. There was a significant decrease in both body and cerebral weight in the restricted animals compared with the control group fed with 23% protein diet. In cerebral cortex CAT activity and its expression were significantly increased in corn fed (C) versus protein restricted (HP) and control (T) animals, without no significant changes in muscarinic receptors number.