Publications by authors named "Raul Bernal Reyes"
Article Synopsis
- Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD) poses an increased risk for cardiovascular issues, and identifying biomarkers for its early detection is particularly important in Latin America.
- The study evaluated sixteen different biomarkers among 161 Mexican individuals to determine their effectiveness in diagnosing MASLD.
- Results showed that the TyG-WC index was the most reliable predictor of MASLD, with significant differences in diagnostic efficacy based on sex.
Background: In both clinical and experimental trials, pirfenidone (PFD) showed anti-inflammatory and antifibrogenic effects. Considering the wide variation in hepatic functional reserve in patients with cirrhosis, we decided to learn more about the pharmacokinetics of a new formulation of prolonged release PFD in this population (PR-PFD), focusing on assessing changes on AUC, AUC, and C.
Methods: In this study, 24 subjects with cirrhosis were included: eight subjects with mild liver impairment (Child-Pugh A) and eight with moderate liver impairment (Child-Pugh B), and a third group of eight age-matched subjects without fibrosis.
Higher cardiovascular risk scores and liver fibrosis risk estimated by biomarkers in patients with metabolic-dysfunction-associated fatty liver disease.
World J Hepatol
August 2022
Background: The definition of metabolic-dysfunction-associated fatty liver disease (MAFLD) allows identification of metabolically complicated patients. Fibrosis risk scores are related to cardiovascular risk (CVR) scores and could be useful for the identification of patients at risk of systemic complications.
Aim: To evaluate the relationship between MAFLD and CVR using the Framingham risk score in a group of Mexican patients.
Objective: To describe the characteristics of the body components and phase angle (PhA) of patients with MAFLD according to those different to fibrosis and hepatic steatosis.
Material And Methods: Observational and descriptive study in a cohort of 585 volunteers from our center with MAFLD criteria. The risk of liver fibrosis was determined by APRI, NAFLD score and FIB-4; at an indeterminate and high risk of fibrosis, a transient elastography (Fibroscan®) were realized.
Objective: To investigate the Liver Functional Test (LFT) and hepatic ultrasound (US) usefulness in the diagnostic of NASH.
Background: NASH is part of NAFLD (non-alcoholic fatty liver disease), this condition can lead to cirrhosis; it is associated with others frequents diseases in Mexico such as type 2 diabetes and obesity. Unfortunately the diagnosis of NASH is not easy, since it must be confirmed by an hepatic biopsy and this requisite can conditionate a subnormal register.
[Trichobezoar: presentation of three cases, clinical and psychological profile].
Rev Gastroenterol Mex
September 2005
Introduction: The description of Trichobezoar is very ancient; it is an occasional entity and it mainly affects young women with deep psychopathology.
Cases Report: Three cases of teenagers with gastric Trichobezoar have been studied; their clinical evolution and diagnostic methods were analyzed. Their psychological profile and familiar environment were particularly studied in our hospital by gastroenterology and psychology.
Background: At the present time, there is no accepted treatment for non-alcoholic steatohepatitis (NASH); nevertheles, there are some reports of non-controlled studies with apparently good answer with ursodeoxycholic acid (UDCA) as much with alpha-tocopherol (aTP).
Objective: To value the clinical, biochemical and hepatic ultrasound (US) response in patients with NASH in treatment for 1 year with UDCA or aTP, as well as to establish tolerance, undesirable effects and fulfillment.
Method: Three patients received UDCA (250 mg TID) and six aTP (100 mg TID).