Determination of local flow ratios and velocities in a femoral venous cannula with computational fluid dynamics and 4D flow-sensitive magnetic resonance imaging: A method validation.

Cannulas with multi-staged side holes are the method of choice for femoral cannulation in extracorporeal therapies today. A variety of differently designed products is available on the market. While the preferred tool for the performance assessment of such cannulas are pressure-flow curves, little is known about the flow and velocity distribution.

Impact of BPRS interview length on ratings reliability in a schizophrenia trial.

Signal detection in clinical trials relies on ratings reliability. We conducted a reliability analysis of site-independent rater scores derived from audio-digital recordings of site-based rater interviews of the structured Brief Psychiatric Rating Scale (BPRS) in a schizophrenia study. "Dual" ratings assessments were conducted as part of a quality assurance program in a 12-week, double-blind, parallel-group study of PF-02545920 compared to placebo in patients with sub-optimally controlled symptoms of schizophrenia (ClinicalTrials.

A comparative analysis between site-based and centralized ratings and patient self-ratings in a clinical trial of Major Depressive Disorder.

We compared scores from three different ratings methods in a clinical trial of patients with Major Depressive Disorder (MDD). The Quick Inventory of Depressive Symptoms (QIDS-SR16) was compared to site-based clinician and centralized (site-independent) ratings of the Inventory of Depressive Symptoms (IDSc30). An extracted QIDSc16 was used for a matched comparison with the QIDS-SR16.

Iron deficiency anaemia over the last decades - Osler's disease diagnosed by Doppler and contrast-enhanced ultrasound.

Case Report: A 72-year-old woman with a 30-year history of iron deficiency anaemia was admitted for fatigue and increasing weakness. On physical examination, the patient appeared dyspneic and pallor. The tongue showed angiodysplasias.

The impact of high-resolution ultrasound in the differential diagnosis of non-hemolytic jaundice.

Because jaundice is a common reason for hospital admission. A fast and correct differential diagnosis is very important to increase treatment efficacy. The aim of our study was to evaluate the impact of the high-resolution ultrasound in this kind of clinical setting.

Biomechanical evaluation of two reconstruction techniques for posterolateral instability of the knee.

We evaluated two reconstruction techniques for a simulated posterolateral corner injury on ten pairs of cadaver knees. Specimens were mounted at 30° and 90° of knee flexion to record external rotation and varus movement. Instability was created by transversely sectioning the lateral collateral ligament at its midpoint and the popliteus tendon was released at the lateral femoral condyle.

Impact of high-resolution transabdominal ultrasound in the diagnosis of complications of Crohn's disease.

Objective: Crohn's disease is associated with intestinal complications such as strictures, fistulas and abscesses. As the management of the patients is influenced by the presence or absence of complication, sensitive diagnostic modalities to detect these complications are needed. The aim of this prospective study was to evaluate the diagnostic accuracy of high-resolution transabdominal ultrasound in the diagnosis of complications of Crohn's disease.

[Ultrasonographic diagnosis of a biliary-digestive fistula with gallstone ileus].

History And Clinical Findings: A 72-year-old woman was admitted to the hospital with upper abdominal pain, nausea, vomiting, and obstipation.

Investigations: Percutaneous ultrasound found aerobilia, a biliary-digestive fistula, and an ileus with gallstones within the small bowel. The findings were confirmed at computed tomography.

Contrast-enhanced sonography in pancreatic diseases.

Contrast-enhanced sonography is a widely available imaging modality for the diagnosis of pancreatic diseases. With this procedure, pancreatic tumours can be differentiated better. Furthermore, contrast-enhanced sonography produces good results in the staging of acute pancreatitis severity, especially in the detection of pancreatic necrosis.

Tunnel convergence in combined anterior cruciate ligament and posterolateral corner reconstruction.

Purpose: To examine the geometric relationship between tunnels created in the lateral femoral condyle in reconstruction of the anterior cruciate ligament (ACL) and the posterolateral structures.

Methods: The geometric relationship between a standard ACL tunnel and 11 lateral femoral tunnel variations in synthetic femur specimens was examined. Tunnel collision frequency and tunnel separation were measured radiographically.

A biomechanical evaluation of transcondylar femoral fixation of anterior cruciate ligament grafts.

Background: Interference screw fixation of the graft in anterior cruciate ligament reconstruction is considered the gold standard, but limited clinical experience suggests that transcondylar fixation is equally effective.

Purpose: To compare transcondylar and interference screw fixation.

Study Design: Ex vivo biomechanical study.