Dry eye disease and morphological changes in the anterior chamber in people with cystic fibrosis.

Background: Cystic fibrosis (CF) is caused by variants in a gene that encodes a protein essential for water and ion transport in the epithelial cells of exocrine organs. Given the possible relationship of this protein and conjunctival and corneal epithelium, the aim of this study was to evaluate ophthalmologic alterations in people with CF.

Methods: Forty-five people with CF underwent pulmonary evaluation including inflammatory score (IS).

Comparison of the effectiveness of 2 shockwave therapy protocols for the treatment of vascular erectile dysfunction: a randomized, multicenter, open-label, noninferiority, phase 4 clinical trial.

Background: Shockwave therapy is an optional adjuvant treatment for vascular erectile dysfunction (ED). There is variability in treatment protocols and challenges with patients adherence to the weekly protocol, which is the most commonly used.

Aim: This study aimed to evaluate the noninferiority of a monthly shockwave therapy protocol compared to the weekly protocol for treating vascular ED.

Modulation of Mitochondria-Endoplasmic Reticulum Contacts (MERCs) by Small Molecules as a New Strategy for Restoring Lipid Metabolism in an Amyotrophic Lateral Sclerosis Model.

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease without effective treatment. The progressive motoneuron death in ALS is associated with alterations in lipid metabolism. As its regulation occurs in mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs), modulation of mitochondria-ER contacts (MERCs) is emerging as a crucial factor in MAM formation and lipid metabolism control.

Development of Texas's First Chinese American Community Health Worker Certification for Family Health History-Based Cancer Prevention.

To address leading health organizations' calls for public health professionals to adopt family health history (FHH) into their practice, we developed the first community health worker Texas state-certification program focusing on FHH-based cancer prevention for Chinese Americans, for whom cancer is the leading cause of death. The 160-hour program trained 46 Chinese American CHWs to provide FHH-based cancer prevention services for 1129 Chinese Americans. Our program contributes to the establishment of a public health workforce with FHH-based competence and reduces cancer disparities.

MicroRNA-199a-5p may be a diagnostic biomarker of primary ITP.

There is no diagnostic test for primary immune thrombocytopenia (ITP). Certain microRNAs have shown to have diagnostic potential in ITP. We validated 12 microRNAs identified from two previous studies to find a diagnostic biomarker.

In Silico and Experimental Evidence for the Stabilization of rhEPO by Glycine, Glutamic Acid and Lysine.

The available literature indicates that amino acids can stabilize proteins. Our experimental data demonstrated that lysine and glutamic acid can stabilize recombinant human erythropoietin (rhEPO) at 40°C for at least 1 month, as measured by RP-UPLC. Studies with different excipient concentrations demonstrated optimal concentrations of these amino acids within 10-12 mM.

Receipt of Family Planning Services in the United States: 2022-2023.

Introduction: This report uses data from the 2022‒2023 National Survey of Family Growth (NSFG) to estimate receipt of family planning services by selected characteristics among females ages 15‒49 in the United States.

Methods: NSFG data were collected through a multi-mode design (in-person and web interviews) with a nationally representative samples of males and females ages 15-49 in the household population of the United States. This report uses data from 5,586 females who completed the survey between January 2022 and December 2023.

Comparison of the lethal triad and the lethal diamond in severe trauma patients: a multicenter cohort.

Background: To reduce the number of deaths caused by exsanguination, the initial management of severe trauma aims to prevent, if not limit, the lethal triad, which consists of acidosis, coagulopathy, and hypothermia. Recently, several studies have suggested adding hypocalcemia to the lethal triad to form the lethal diamond, but the evidence supporting this change is limited. Therefore, the aim of this study was to compare the lethal triad and lethal diamond for their respective associations with 24-h mortality in severe trauma patients receiving transfusion.

Optogenetic control of horizontally acquired genes prevent stuck fermentations in yeast.

Nitrogen limitations in the grape must be the main cause of stuck fermentations during the winemaking process. In , a genetic segment known as region A, which harbors 12 protein-coding genes, was acquired horizontally from a phylogenetically distant yeast species. This region is mainly present in the genome of wine yeast strains, carrying genes that have been associated with nitrogen utilization.

Evaluation and Characterization of Functionally Graded Adhesive Joints: Experimental and Numerical Analyses.

Epoxy resins have exhibited exceptional performance in engineering applications, particularly as a replacement for traditional mechanical joints in adhesive bonding. This study evaluates the suitability of two innovative adhesives, SikaPower-1511 and SikaPower-1548, in various graded configurations. The thermal curing behavior of the adhesives was analyzed using differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR).

Evaluating the Effects of Sugar Shift Symbiotic on Microbiome Composition and LPS Regulation: A Double-Blind, Placebo-Controlled Study.

(1) Background: This study evaluated the effects of BiotiQuest Sugar Shift, a novel probiotic formulation, for its impact on gut microbiome composition and metabolic health in type 2 diabetes mellitus (T2D). T2D is characterized by chronic inflammation and gut microbiome imbalances, yet the therapeutic potential of targeted probiotics remains underexplored. (2) Methods: In a 12-week randomized, double-blind, placebo-controlled trial, 64 adults with T2D received either Sugar Shift or placebo capsules twice daily.

Dissolution Thermodynamics of the Solubility of Sulfamethazine in (Acetonitrile + 1-Propanol) Mixtures.

: Solubility is one of the most important parameters in the research and development processes of the pharmaceutical industry. In this context, cosolubility is one of the most used strategies to improve the solubility of poorly soluble drugs, besides allowing to identify some factors involved in the dissolution process. The aim of this research is to evaluate the solubility of sulfamethazine in acetotinitrile + 1-propanol cosolvent mixtures at 9 temperatures (278.

Comparison of Sulfamethoxazole Removal Efficiency Using Polyethersulfone Ultrafiltration Membrane Modified by Various Methods.

Nowadays, there is a growing interest in membrane modification processes to improve their characteristics and the effectiveness of their treatments and reduce the possible fouling. In this sense, in this work, a modification of an ultrafiltration membrane with three different materials has been carried out: reduced graphene oxide (rGO), chitosan and MgCl. For both the native and the modified membranes, a study has been carried out to remove the emerging contaminant sulfamethoxazole (SMX).

Are Healthcare Resource Utilization Patterns for Pain Management Specific to Post-Acute COVID-19 Syndrome? A Study of Survivors from the First French Pandemic Wave.

Chronic pain is a common symptom in Post-Acute COVID-19 Syndrome (PACS), affecting 11-60% of patients, but the link between COVID-19 and chronic pain remains unclear. This study assesses healthcare resource utilization (HRU) for pain management among French COVID-19 survivors, using the National French Claims Database (SNDS). We analyzed medical consultations, rehabilitation services, diagnostic procedures, and medication dispensing to identify PACS-related pain patterns and their impact on the healthcare system.

Exposure to Environmental Chemicals and Infertility Among US Reproductive-Aged Women.

Environmental chemical exposure has been rising over the past few decades but its impact on fertility remains uncertain. We assessed exposures to 23 common chemicals across a range of sociodemographic characteristics and their relationship with self-reported infertility. The analytic sample was non-pregnant women aged 18-49 years without a history of hysterectomy or oophorectomy (n = 2579) from the National Health and Nutrition Examination Survey (2013-2016).

Efficacy of the reGENER@r Program on Socio-Emotional Skills and Sexist Beliefs in Perpetrators of Gender-Based Violence: A Pilot Study in Spain.

Background: Gender-based violence (GBV) is one of the most pronounced expressions of the unequal power relations between women and men. As a tool for action against this phenomenon, psychological intervention programs for perpetrators of GVB are offered. This is how reGENER@r was born; it is a two-month program based on psychoeducational and cognitive-behavioral strategies that is part of the alternative measures to GBV-related prison sentences.

Student Violence Against Paraprofessionals in Schools: A Social-Ecological Analysis of Safety and Well-Being.

Violence against teachers has received increasing attention worldwide, with high rates of verbal, threatening, physical, and property violence in schools. Teacher-directed violence contributes to poor mental and physical health, high rates of turnover, and diminished student achievement. Despite these findings, there is a dearth of research on violence experienced by paraprofessionals who play key roles in supporting students with the greatest learning and behavioral needs in schools.

Health and Liver Diagnostic Markers Influencing Glycemia in Subjects with Prediabetes: Preview Study.

Introduction: Glucose homeostasis may be dependent on liver conditions and influence health-related markers and quality of life (QoL) objective measurements. This study aimed to analyze the interactions of glycemia with liver and health status in a prediabetic population.

Subjects And Methods: This study included 2220 overweight/obese prediabetics from the multinational PREVIEW project.

Phytochemistry, Anti-cancer, and Anti-diabetic Properties of Plant-Based Foods from Mexican Agrobiodiversity: A Review.

Type 2 diabetes mellitus (T2DM) and cancer are significant contributors to morbidity and mortality worldwide. Recent studies have increasingly highlighted the potential of phytochemicals found in plants and plant-based foods for preventing and treating these chronic diseases. Mexico's agrobiodiversity provides a valuable resource for phytochemistry.

Evaluation of Antioxidant and Antimicrobial Properties of Murtilla Leaves (.) in Beef Patties: Effects on Quality Parameters and Shelf Life.

Beef patties are highly consumed worldwide. However, its formulations often include synthetic antioxidants and antimicrobials. Murtilla (.

Ancient DNA Reveals the Earliest Evidence of Sheep Flocks During the Late Fourth and Third Millennia BC in Southern Iberia.

The Spanish Merino is the most significant sheep breed globally due to its economic and cultural importance in human history. It has also had a substantial influence on the development of other Merino and Merino-derived breeds. Historical sources indicate that crossbreeding to produce finer, higher-quality wool was already taking place in the south of the Iberian Peninsula during the Roman era.

Drivers of Seasonal Change of Avian Communities in Urban Parks and Cemeteries of Latin America.

Urban parks and cemeteries constitute hot spots of bird diversity in urban areas. However, the seasonal dynamics of their bird communities have been scarcely explored at large scales. This study aims to analyze the drivers of urban bird assemblage seasonality in urban parks and cemeteries comparing assemblages during breeding and non-breeding seasons in the Neotropical Region.

Synthesis and Characterization of Antibacterial Poly{2-[(methacryloyloxy)ethyl]trimethylammonium Chloride}/Chitosan Semi-Interpenetrating Networks for Papain Release.

Annually, thousands of individuals suffer from skin injuries resulting from trauma, surgeries, or diabetes. Inadequate wound treatment can delay healing and increase the risk of severe infections. In this context, a promising synthetic polymer with potent antimicrobial properties, Poly{2-[(methacryloyloxy)ethyl]trimethylammonium chloride} (PMETAC), is synthesized and crosslinked with N,N'-Methylenebis(acrylamide) (BIS) in the presence of Chitosan (CH), a natural, biocompatible polysaccharide that promotes cell regeneration and provides additional beneficial properties.

A signaling inspired synthetic toolkit for efficient production of tyrosine phosphorylated proteins.

Tyrosine phosphorylation is an important post-translational modification that regulates many biochemical signaling networks in multicellular organisms. To date, 46,000 tyrosines have been observed in human proteins, but relatively little is known about the function and regulation of most of these sites. A major challenge has been producing recombinant phospho-proteins in order to test the effects of phosphorylation.