SEIS: Insight's Seismic Experiment for Internal Structure of Mars.

Unlabelled: By the end of 2018, 42 years after the landing of the two Viking seismometers on Mars, InSight will deploy onto Mars' surface the SEIS (eismic xperiment for nternal tructure) instrument; a six-axes seismometer equipped with both a long-period three-axes Very Broad Band (VBB) instrument and a three-axes short-period (SP) instrument. These six sensors will cover a broad range of the seismic bandwidth, from 0.01 Hz to 50 Hz, with possible extension to longer periods.

French updated recommendations in Stage I to III melanoma treatment and management.

As knowledge continues to develop, regular updates are necessary concerning recommendations for practice. The recommendations for the management of melanoma stages I to III were drawn up in 2005. At the request of the Société Française de Dermatologie, they have now been updated using the methodology for recommendations proposed by the Haute Autorité de Santé in France.

[Update to the recommendations for management of melanoma stages I to III].

As knowledge continues to develop, regular updates are necessary concerning recommendations for practice. The recommendations for the management of melanoma stages I to III were drawn up in 2005. At the request of the Société Française de Dermatologie, they have now been updated using the methodology for recommendations proposed by the Haute Autorité de Santé.

Melanoma-associated retinopathy treated with ipilimumab therapy.

Melanoma-associated retinopathy (MAR) is a rare autoimmune syndrome in patients with melanoma characterized by visual disorders. MAR is induced by the degeneration of bipolar cells of the retina and the presence of serum autoantibodies against retina proteins. Ipilimumab, an anti-cytotoxic T lymphocyte-associated antigen 4 antibody, improves survival in previously treated patients with metastatic melanoma, but is responsible for a spectrum of immune-related adverse events.

[Management of adverse effects of targeted therapy toxicities in oncology].

During the past few years, medical treatments of cancer have improved thanks to the discovery of targeted therapies. These therapies are today widely used in cancer treatment. The mechanism of action of targeted therapies and the adverse effects they induce are different from the classic chemotherapies, and require a specific management.

[Intracranial extension of cutaneous facial squamous cell carcinoma: involvement of the neurotropic pathway].

Background: Squamous cell carcinoma is the most common form of skin cancer after basal cell carcinoma. It comprises locoregional malignant tumours with more rapid and severe spread, and which may metastasise through blood or lymph, and through a less well-known neurotropic pathway. We report a case of late and slowly progressive recurrence of squamous cell carcinoma revealed and characterized by neurological symptoms alone.

Management and outcome of metastatic melanoma during pregnancy.

Background: Although metastatic melanoma occurrence during pregnancy challenges the physician in several ways, only a few studies have been published.

Objectives: Our aim was to investigate therapeutic management together with maternal and fetal outcomes in pregnant women with advanced melanoma.

Methods: A French national retrospective study was conducted in 34 departments of Dermatology or Oncology.

Early 2'-deoxy-2'-[18F]fluoro-D-glucose PET metabolic response after corticosteroid therapy to differentiate cancer from sarcoidosis and sarcoid-like lesions.

Purpose: We aimed at investigating whether early metabolic response to corticosteroid therapy may be used as a diagnostic tool to discriminate between cancer and sarcoidosis, a well-known cause of false-positive 2-deoxy-2-[F-18]fluoro-D: -glucose-positron emission tomography (FDG-PET) findings in oncology.

Procedure: Two cancer patients with biopsy-proven sarcoidosis or sarcoid-like reaction had multiple thoracic FDG foci. After infectious disease had been excluded, patients received oral corticosteroids for 16 and 14 days, respectively, and underwent posttherapeutic FDG-PET examination.

[Psoriatic onycho-pachydermo-periostitis].

Psoriatic-onycho-pachydermo-periostitis is a particular form of psoriatic arthropathy recently described, which combine psoriatic onychosis, thickening of the distal soft tissues and osteo-periostitis of the distal phalanx without lesion of the interphalangeal joint. Biological examinations are normal. Radiological lesions show a phalanx condensation which gives a spicule aspect.