MIML: multiplex image machine learning for high precision cell classification via mechanical traits within microfluidic systems.

Label-free cell classification is advantageous for supplying pristine cells for further use or examination, yet existing techniques frequently fall short in terms of specificity and speed. In this study, we address these limitations through the development of a novel machine learning framework, Multiplex Image Machine Learning (MIML). This architecture uniquely combines label-free cell images with biomechanical property data, harnessing the vast, often underutilized biophysical information intrinsic to each cell.

Influence of Keto-Enol Tautomerism in Regulating CO Photoreduction Activity in Porous Organic Porphyrinic Photopolymers.

Photoassisted CO reduction employing a metal-free system is both challenging and fascinating. In our study, we present a structural engineering strategy to tune the potential energy barrier, which, in turn, affects the photoreduction ability. A series of porphyrin-based porous organic polymers () were hydrothermally synthesized and the influence of keto-enol tautomerization on the CO photoreduction potential has been rigorously investigated.

Site-Selective Zn-Metalation in Poly-Triphenyl Amine-based Porous Organic Polymer for Solid-Gas Phase CO Photoreduction.

Harvesting solar energy to produce value-added chemicals from carbon dioxide (CO) presents a promising route for addressing the complexities of sustainable energy systems and environmental issues. In this context, the development of metal-coordinated porous organic polymers (POPs) offers a vital avenue for improving the photocatalytic performance of organic motifs. The current study presents a metal-integrated photocatalytic system (namely, ) developed via a one-pot Friedel-Crafts (F.

Harmonizing Between Chemical Functionality and Surface Area of Porous Organic Polymeric Nanotraps for Tuning Carbon Dioxide Capture.

The energy sector has demonstrated significant enthusiasm for investigating post-combustion CO capture, storage, and separation. However, the practical application of current porous adsorbents is impeded by challenges related to cost competitiveness, stability, and scalability. Intregation of heteroatoms in the porous organic polymers (POPs) dispense it more susceptible for CO adsorption to attenuate green house gases.

Microphysiologically Engineered Vessel-Tumor Model to Investigate Vascular Transport Dynamics of Immune Cells.

Cancer immunotherapy has emerged as a promising therapeutic strategy to combat cancer effectively. However, it is hard to observe and quantify how this in vivo process happens. Three-dimensional (3D) microfluidic vessel-tumor models offer valuable capability to study how immune cells transport during cancer progression.

Purification of Waste-Generated Biogas Mixtures Using Covalent Organic Framework's High CO Selectivity.

Development of crystalline porous materials for selective CO adsorption and storage is in high demand to boost the carbon capture and storage (CCS) technology. In this regard, we have developed a β-keto enamine-based covalent organic framework () via the Schiff base polycondensation technique. The as-synthesized exhibited excellent thermal and chemical stability along with a very high surface area (1258 m g) and a high CO adsorption capacity (3.

Catching an Oxo Vanadate Porous Acetylacetonate Covalent Adaptive Catalytic Network that Renders Mustard-Gas Simulant Harmless.

In this work, we illustrated the design and development of a metal-coordinated porous organic polymer () namely a post-synthetic metalation strategy to incorporate oxo-vanadium sites in a pristine polymer () having acetylacetonate (acac) as anchoring moiety. The as-synthesized exhibited highly robust and porous framework, which has been utilized for thioanisole (TA) oxidation to its corresponding sulfoxide. The catalyst demonstrated notable stability and recyclability by maintaining its catalytic activity over multiple reaction cycles without any significant loss in activity.

Multiplex solid-phase RPA coupled CRISPR-based visual detection of SARS-CoV-2.

The COVID-19 pandemic has presented a significant challenge to the world's public health and led to over 6.9 million deaths reported to date. A rapid, sensitive, and cost-effective point-of-care virus detection device is essential for the control and surveillance of the contagious severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic.

Pyrolysis Free Out-of-Plane Co-Single Atomic Sites in Porous Organic Photopolymer Stimulates Solar-Powered CO Fixation.

Herein, a facile strategy is illustrated to develop pyrolysis-free out-of-plane coordinated single atomic sites-based M-POP via a one-pot Friedel Craft acylation route followed by a post-synthetic metalation. The optimized geometry of the Co@BiPy-POP clearly reveals the presence of out-of-plane Co-single atomic sites in the porous backbone. This novel photopolymer Co@BiPy-POP shows extensive π-conjugations followed by impressive light harvesting ability and is utilized for photochemical CO fixation to value-added chemicals.

Tweaking Photo CO Reduction by Altering Lewis Acidic Sites in Metalated-Porous Organic Polymer for Adjustable H /CO Ratio in Syngas Production.

Herein, we have specifically designed two metalated porous organic polymers (Zn-POP and Co-POP) for syngas (CO+H ) production from gaseous CO . The variable H /CO ratio of syngas with the highest efficiency was produced in water medium (without an organic hole scavenger and photosensitizer) by utilizing the basic principle of Lewis acid/base chemistry. Also, we observed the formation of entirely different major products during photocatalytic CO reduction and water splitting with the help of the two catalysts, where CO (145.

MIML: Multiplex Image Machine Learning for High Precision Cell Classification via Mechanical Traits within Microfluidic Systems.

Label-free cell classification is advantageous for supplying pristine cells for further use or examination, yet existing techniques frequently fall short in terms of specificity and speed. In this study, we address these limitations through the development of a novel machine learning framework, Multiplex Image Machine Learning (MIML). This architecture uniquely combines label-free cell images with biomechanical property data, harnessing the vast, often underutilized biophysical information intrinsic to each cell.

Rapid prototyping of high-resolution large format microfluidic device through maskless image guided in-situ photopolymerization.

Microfluidic devices have found extensive applications in mechanical, biomedical, chemical, and materials research. However, the high initial cost, low resolution, inferior feature fidelity, poor repeatability, rough surface finish, and long turn-around time of traditional prototyping methods limit their wider adoption. In this study, a strategic approach to a deterministic fabrication process based on in-situ image analysis and intermittent flow control called image-guided in-situ maskless lithography (IGIs-ML), has been proposed to overcome these challenges.

Linker Independent Regioselective Protonation Triggered Detoxification of Sulfur Mustards with Smart Porous Organic Photopolymer.

The development of efficient metal-free photocatalysts for the generation of reactive oxygen species (ROS) for sulfur mustard (HD) decontamination can play a vital role against the stockpiling of chemical warfare agents (CWAs). Herein, one novel concept is conceived by smartly choosing a specific ionic monomer and a donor tritopic aldehyde, which can trigger linker-independent regioselective protonation/deprotonation in the polymeric backbone. In this context, the newly developed vinylene-linked ionic polymers (TPA/TPD-Ionic) are further explored for visible-light-assisted detoxification of HD simulants.

Experimental Validation and Computational Predictions Join Forces to Map Catalytic C-H Activation in Ferrocene Metalated Porous Organic Polymers.

In recent times, a self-complementary balanced characteristic feature with the combination of both covalent bonds (structural stability) and open metal sites (single-site catalysis) introduced an advanced emerging functional nanoarchitecture termed metalated porous organic polymers (M-POPs). However, the development of M-POPs in view of the current interest in catalysis has been realized still in its infancy and remains a challenge for the years to come. In this work, we built benzothiazole-linked Fe-metalated porous organic polymer () using ferrocene dicarboxaldehyde (), 1,3,5-tris(4-aminophenyl) benzene (), and elemental sulfur (S) via a template-free, multicomponent, cost-effective one-pot synthetic approach.

Putting forward a Ni-metallosalphen-based porous organic polymer for detoxification of sulfur mustard gas simulant.

We have introduced a Friedel-Crafts alkylation strategy of a Ni-salphen complex as derived from 2-hydroxy-5-methoxybenzaldehyde, an isomer of biomass derived vanillin, to construct a Ni-salphen based porous organic polymer (Ni@T-POP). The X-ray absorption spectroscopy (XAS) analysis revealed the existence of Ni-NO core sites in the Ni@T-POP framework, which demonstrates unprecedented catalytic efficiency towards oxidative decontamination of sulfur mustards (HD's) compared to its complex precursor.

Hierarchical Vessel Network-Supported Tumor Model-on-a-Chip Constructed by Induced Spontaneous Anastomosis.

The vascular system in living tissues is a highly organized system that consists of vessels with various diameters for nutrient delivery and waste transport. In recent years, many vessel construction methods have been developed for building vascularized on-chip tissue models. These methods usually focused on constructing vessels at a single scale.

Tuning of Microenvironment in Covalent Organic Framework via Fluorination Strategy promotes Selective CO Capture.

Herein, we have designed and synthesized two heteroatom (N, O) rich covalent organic frameworks (COF), PD-COF and TF-COF, respectively, to demonstrate their relative effect on CO adsorption capacity and also CO /N selectivity. Compared to the non-fluorinated PD-COF (BET surface area 805 m  g , total pore volume 0.3647 ccg ), a decrease in BET surface area and also pore volume have been observed for fluorinated TF-COF due to the incorporation of fluorine to the porous framework (BET surface area 451 m  g , total pore volume 0.

Selective photocatalytic CO reduction to CH over metal-free porous polyimide in the solid-gas mode.

Using a catalyst-free one-pot polycondensation approach, a new donor-acceptor (D-A) based porous polyimide (PeTt-POP) photocatalyst was developed. PeTt-POP produced CH (125.63 ppm g in 6 h) from CO under visible light irradiation in the gas-solid mode without the use of co-catalysts or sacrificial agents.

Adaptable Microfluidic Vessel-on-a-Chip Platform for Investigating Tumor Metastatic Transport in Bloodstream.

Cancer metastasis counts for 90% of cancer fatalities, and its development process is still a mystery. The dynamic process of tumor metastatic transport in the blood vessel is not well understood, in which some biomechanical factors, such as shear stress and various flow patterns, may have significant impacts. Here, we report a microfluidic vessel-on-a-chip platform for recapitulating several key metastatic steps of tumor cells in blood vessels on the same chip, including intravasation, circulating tumor cell (CTC) vascular adhesion, and extravasation.

Unlocking Molecular Secrets in a Monomer-Assembly-Promoted Zn-Metalated Catalytic Porous Organic Polymer for Light-Responsive CO Insertion.

Anthropogenic carbon dioxide (CO) emission is soaring day by day due to fossil fuel combustion to fulfill the daily energy requirements of our society. The CO concentration should be stabilized to evade the deadly consequences of it, as climate change is one of the major consequences of greenhouse gas emission. Chemical fixation of CO to other value-added chemicals requires high energy due to its stability at the highest oxidation state, creating a tremendous challenge to the scientific community to fix CO and prevent global warming caused by it.

Ferrocene-derived Fe-metalated porous organic polymer for the core planarity-triggered detoxification of chemical warfare agents.

Herein, we demonstrate the successful construction of two Fe-metalated porous organic polymers having planar (Fe-Tt-POP) and non-planar (Fe-Rb-POP) geometry the ternary copolymerization strategy for the catalytic oxidative decontamination of different sulfur-based mustard gas simulants (HD). Fe-Tt-POP exhibits superior catalytic performance for the oxidation of thioanisole (TA) in comparison with Fe-Rb-POP. Interestingly, this activity difference can be further explored by operando DRIFTS and DFT computational studies.

Organogel-assisted porous organic polymer embedding Cu NPs for selectivity control in the semi hydrogenation of alkynes.

Heteroatom-rich porous-organic-polymers (POPs) comprising highly cross-linked robust skeletons with high physical and thermal stability, high surface area, and tunable pore size distribution have garnered significant research interest owing to their versatile functionalities in a wide range of applications. Here, we report a newly developed organogel-assisted porous-organic-polymer (POP) supported Cu catalyst (Cu@TpRb-POP). The organogel was synthesized a temperature induced gelation strategy, employing Schiff-base coupling between 2,4,6-triformylphloroglucinol aldehyde (Tp) and pararosaniline base (Rb).

Nanoarchitectonics of Metal-Free Porous Polyketone as Photocatalytic Assemblies for Artificial Photosynthesis.

The main component of natural gas is methane, whose combustion contributes to global warming. As such, sustainable, energy-efficient, nonfossil-based methane production is needed to satisfy current energy demands and chemical feedstocks. In this article, we have constructed a metal-free porous polyketone () with donor-acceptor (D-A) groups with an extensive π-conjugation by facile Friedel-Crafts acylation reaction between triphenylamine () and pyridine-2,6-dicarbonyl dichloride ().