Designing a next generation multi-epitope based peptide vaccine candidate against SARS-CoV-2 using computational approaches.

Unlabelled: COVID-19 caused by SARS-CoV-2 was declared a global pandemic by WHO (World Health Organization) in March, 2020. Within 6 months, nearly 750,000 deaths are claimed by COVID-19 across the globe. This called for immediate social, scientific, technological, public and community interventions.

Ameliorative effect of chitosan-conjugated 17α-methyltestosterone on testicular development in Clarias batrachus.

Chitosan nanoparticles conjugated with 17α-methyltestosterone (CS + MT) were used for studying their effect on the testicular development of Clarias batrachus during different reproductive phases. The size of chitosan nanoparticles was 127.2 nm and the nano-conjugated 17α methyltestosterone (17α-MT) was 196.

Expression analysis of Sox9 genes during annual reproductive cycles in gonads and after nanodelivery of LHRH in Clarias batrachus.

Transcription factor Sox9 plays a crucial role in determining the fate of several cell types and is a primary factor in regulation of gonadal development. Present study reports full-length cDNA sequence of Sox9a gene and partial coding sequence (cds) of Sox9b (two duplicate orthologs of Sox9 gene) from Clarias batrachus. The coding region of Sox9a gene encoded a peptide of 460 amino acids.

Maximum aerobic capacity of underground coal miners in India.

Miners fitness test was assessed in terms of determination of maximum aerobic capacity by an indirect method following a standard step test protocol before going down to mine by taking into consideration of heart rates (Telemetric recording) and oxygen consumption of the subjects (Oxylog-II) during exercise at different working rates. Maximal heart rate was derived as 220-age. Coal miners reported a maximum aerobic capacity within a range of 35-38.

A comparison of cardiac strain among drillers of two different age groups in underground manual coal mines in India.

Cardiac strain was evaluated in terms of working heart rate (WHR), relative cardiac cost (RCC), net cardiac cost (NCC) and other recovery indices among six younger (mean age 34.2 +/- 2.7 yr) and sixteen older (mean age 48.

A comparison of physiological strain of carriers in underground manual coal mines in India.

Thirty-nine healthy carriers (23-57 years of age) were investigated in underground manual coal mines in West Bengal, India during two different work spells of a single work shift. We compared physiological strain of workers <40 and > or =40 years of age. For both groups, mean heart rate was 124-133 beats/min, with a mean corresponding relative cardiac cost of 50-66%.

A comparative study of physiological strain of underground coal miners in India.

Ninety-eight healthy underground coal miners aged between 23-58 years were studied during their activity period. Physiological strain of different category of miners in terms of heart rate was monitored continuously with heart rate monitor that revealed the tasks as heavy to very heavy for them. Oxygen consumption was measured directly by using oxylog-2 machine that corresponded to metabolic costs for different activities ranging from 4.

Cardiovascular load assessment of coal mine shovelers in west Bengal, India: a comparison between middle age groups.

Cardiovascular load of underground shovelers was assessed in terms of heart rate changes at work in haulage coalmines. Twenty underground shovelers of two different age groups (those of age 31-39 and those of age 40-49) served as subjects. Working heart rate was significantly higher (p < 0.

A study of the workload of underground trammers in the Ranigang coal field area of West Bengal, India.

Thirty healthy trammers were examined in underground haulage mines during their normal activity. Physiological strain in terms of heart rate (HR) varied between 101.6 and 104.