Publications by authors named "Ratna Mukhopadhyay"
Article Synopsis
- Sarcomatoid dedifferentiation occurs in various renal cell carcinoma subtypes, including chromophobe RCC, leading to more aggressive disease and resistance to treatments, but increased response to immunotherapy.
- Research on ChRCC reveals that it can dedifferentiate into sarcomatoid, anaplastic, and glandular forms, which are all linked to enhanced aggressiveness and metastasis.
- Key mutations, like those in TP53 and PTEN, drive this dedifferentiation process, and specific genetic and molecular markers could help classify and diagnose these aggressive tumors more effectively.
Despite the known importance of androgen receptor (AR) signaling in prostate cancer, the processes downstream of AR that drive disease development and progression remain poorly understood. This knowledge gap has thus limited the ability to treat cancer. Here, it is demonstrated that androgens increase the metabolism of glutamine in prostate cancer cells.
View Article and Find Full Text PDFBackground: BK polyoma virus (BKV) has emerged as an important cause of acute and chronic allograft injury in renal transplant recipients. Reactivation of latent infection requires reduction in cell-mediated immunity. We hypothesized that BKV could get reactivated in the urinary tract of patients with end-stage renal disease (ESRD) and impact the allograft function after these individuals undergo transplantation.
View Article and Find Full Text PDF