Publications by authors named "Ratika Krishnamurty"
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Synopsis of recent research by authors named "Ratika Krishnamurty"
- Ratika Krishnamurty's research primarily focuses on understanding the regulation and interactions of Src-family kinases (SFKs) and protein kinases, which are vital for signal transduction and are significant targets in drug discovery aimed at various diseases.
- Her work has advanced the development of innovative chemical proteomic tools, including affinity-based probes and active site profiling methods, that enable detailed study of kinase activity and inhibitor selectivity in complex biological environments.
- Krishnamurty's findings highlight important biochemical mechanisms underlying drug resistance in small-molecule protein kinase inhibitors, underscoring the challenges posed by the conserved nature of the ATP-binding pocket in these enzymes.
