Publications by authors named "Rathna J Veeramachaneni"
Biophys Rep (N Y)
December 2024
Article Synopsis
- Chemical cross-linking coupled with mass spectrometry (CX-MS) effectively identifies distance constraints in macromolecular protein complexes, providing insights into structures under near-native conditions.
- This study focused on the human α1 glycine receptor (α1 GlyR), using a site-specific chemical cross-linking strategy at position 41 to examine its configuration in the apo state.
- The results demonstrated significant cross-linking sites both within and between subunits of α1 GlyR, showcasing CX-MS as a valuable method for understanding the structural dynamics of integral membrane protein assemblies.
