Publications by authors named "Rathat G"
Endoscopic prophylactic nipple-sparing mastectomy: First French survey of 10 patients.
J Gynecol Obstet Hum Reprod
January 2025
Article Synopsis
- The study evaluates the feasibility and safety of the Endoscopic Nipple Sparing Mastectomy (E-NSM) technique for women at high risk of breast cancer, focusing on performing the surgery with minimal incisions and immediate reconstruction.
- A total of 10 patients underwent the procedure with a complete success rate, showing only a small percentage of complications, primarily minor issues like skin necrosis and hematomas.
- Patients reported high satisfaction with the esthetic results, leading to a recommendation for the technique; however, further research involving a larger patient group is needed for validation.
Article Synopsis
- A study analyzed the relationship between the volume of ovarian cancer surgeries at hospitals in France and patient outcomes, focusing on data from 2012 to 2016.
- It included 8429 patients and found that those treated in hospitals performing at least 20 surgeries per year had better 5-year overall survival (OS) rates compared to those in lower-volume hospitals.
- The findings indicate that high-volume hospitals (≥ 20 cases/year) are linked to improved patient outcomes, particularly when compared to hospitals performing fewer than 10 surgeries per year, highlighting the importance of surgical experience in treating ovarian cancer.
Article Synopsis
- A personalized 3D breast model could enhance patient-surgeon discussions and surgical planning by accurately simulating breast tissue properties.
- The study aimed to measure breast skin thickness and the stiffness of different breast tissues, considering factors like age, BMI, and menopausal status as potential influences.
- Results indicated that menopausal status significantly impacted breast skin thickness and stiffness, with average measurements found to be 1.83 mm for skin thickness and 39 kPa for breast tissue stiffness, and future work will focus on integrating these findings into a biomechanical model.
Article Synopsis
- This study investigates the effects of whole-body cryotherapy (WBC) on joint pain caused by aromatase inhibitors in breast cancer patients, aiming to determine if WBC can alleviate pain better than a placebo treatment.* -
- It is a randomized, double-blind, placebo-controlled clinical trial with 56 participants experiencing significant joint pain, measuring outcomes like pain severity and quality of life at various time points post-treatment.* -
- Ethics approval has been secured, and the findings will be shared in a peer-reviewed journal and at international conferences to inform future treatment approaches.*
Purpose: Anatomical knowledge of medical students and residents is insufficient and further anatomical sciences throughout medical curriculum may be necessary. The first aim of this study was to assess pelvic and perineal anatomical knowledge retention of Obstetrics and Gynaecology (Ob/Gyn) residents. The second was to assess the impact of an e-learning tool on anatomical knowledge.
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- * CTCs were found primarily in the ovarian vein samples of 8 out of 10 patients, with no significant differences in the number of CTCs based on age, tumor grade, FIGO stage, or tumor size.
- * The study identified estrogen receptor-positive CTCs and clusters, indicating a need for further research on the potential prognostic and therapeutic implications of CTCs during EC surgery.
Long-term quality of life after surgical Essure removal for device-attributed symptoms.
Eur J Obstet Gynecol Reprod Biol
January 2023
Article Synopsis
- The study looked at how patients felt after having their Essure devices surgically removed, checking their quality of life (QoL) and any symptoms they had before and after the surgery.
- 65 patients had the surgery, and while many felt better after 3 months and 4 years, some still had problems or didn't improve at all.
- The researchers found that mental health issues like anxiety were more common before the surgery but improved afterwards; they suggest more research to fully understand the risks and benefits of this surgery.
Article Synopsis
- About 7% of breast cancer cases are diagnosed in women under 40, which raises important questions about fertility preservation options during treatment.* -
- A study of over 15,000 women in France showed that the fertility preservation rate increased to 17% by 2019 but dropped to 13.9% in 2020, with most births occurring through spontaneous pregnancies.* -
- Among women who preserved their fertility, 19.6% had a live birth after treatment compared to only 3.9% in those who did not preserve fertility, indicating significantly better outcomes for the FP group.*
Interest of para-aortic lymphadenectomy for locally advanced cervical cancer in the era of PET scanning.
Eur J Obstet Gynecol Reprod Biol
May 2022
Article Synopsis
- The study focuses on evaluating the effectiveness of PET-CT scans for staging lymph nodes in patients with locally advanced cervical cancer (LACC) who underwent treatment with pelvic chemoradiotherapy.
- Researchers analyzed data from 71 patients who had PET-CT scans followed by a surgical procedure called para-aortic lymphadenectomy, assessing the accuracy of the scans through various metrics like sensitivity and specificity.
- The results showed that while the PET-CT had a high specificity (84%) and negative predictive value (93%), its overall sensitivity (55%) and positive predictive value (33%) were lower, suggesting the need for surgical staging in certain high-risk cases despite a negative PET-CT result.
Article Synopsis
- The study aimed to demonstrate a fertility-sparing approach for managing an atypical uterine myoma in a 32-year-old woman with a history of menstrual pain.
- A step-by-step video detailed a transcervical biopsy performed under ultrasound guidance, followed by a minimally invasive myomectomy, ultimately allowing the patient to retain fertility.
- The results showed that the biopsy was safe and effective, diagnosing a benign condition and confirming the success of the surgical procedure.
[Identification of sentinel lymph node: Comparison between SNOLL and routine isotopic procedure].
Gynecol Obstet Fertil Senol
March 2021
Introduction: Axillary staging remains the most accurate predictive factor for recurrence risk and survival in patients with invasive breast carcinoma. Sentinel Node Occult Lesion Localization (SNOLL) allows with a single intra-lesion injection both localization of impalpable breast lesion and sentinel node biopsy. Our aim was to compare the efficacy of SNOLL and standard radio isotopic method for sentinel node localization by lymphoscintigraphy.
View Article and Find Full Text PDFPurpose: The outcome of locally advanced cervical cancer (LACC) is dismal. Biomarkers are needed to individualize treatments and to improve patient outcomes. Here, we investigated whether coexpression of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 3 (HER3) could be an outcome prognostic biomarker, and whether targeting both EGFR and HER3 with a dual antibody (MEHD7945A) enhanced ionizing radiation (IR) efficacy.
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- Endoscopic nipple-sparing mastectomy (NSM) can improve patient satisfaction but is not widely used due to technical challenges; implant-based reconstruction (IBR) is currently the most common breast reconstruction method.
- A case study of a 45-year-old woman undergoing NSM with a minimal 4 cm scar showed successful outcomes with no complications at 6 months post-surgery and high patient satisfaction.
- This technique presents a cost-effective alternative to robotic surgery, enabling safer prepectoral implant placement without needing Acellular Dermal Matrix (ADM) and reducing complication risks.
Article Synopsis
- Preoperative localization techniques for occult breast cancer, such as radioisotopic localization and wire localization, can be invasive and uncomfortable; a new virtual localization method was evaluated in this study.
- The study involved nine patients from 2016 to 2017 who had radioisotopic localization combined with preoperative prone MRI and intraoperative 3D optical scanning to improve tumor localization.
- The results showed successful tumor localization with a distance of 1.4 cm in patients with small breasts and 2.8 cm in larger breasts; further optimization and the potential addition of augmented reality could improve this noninvasive technique for future studies.
Article Synopsis
- Cowden syndrome (CS) is a genetic disorder marked by macrocephaly, skin lesions, and heightened risk of certain cancers, especially breast and thyroid cancers.
- A 28-year-old woman with CS developed ovarian clear cell carcinoma (OCCC) and exhibited related physical symptoms and family cancer history.
- Genetic testing revealed a pathogenic variant in her tumor, suggesting a link between CS and her OCCC, which prompts reconsideration of the cancer spectrum associated with Cowden syndrome.
Article Synopsis
- The study aimed to identify CT findings that can accurately diagnose adnexal torsion in women with abdominal pain and an adnexal mass.
- It involved reviewing CT images of 32 patients with torsion and 32 control patients, determining five key features linked to torsion, with the inter-utero-ovarian mass being the most significant predictor.
- The conclusion highlights that the inter-utero-ovarian mass is a reliable indicator for diagnosing adnexal torsion, demonstrating high sensitivity and specificity in CT scans.
Article Synopsis
- Carcinoma of the recto-vaginal septum is a rare cancer often linked to ovarian and peritoneal cancers, with a generally poor prognosis documented in existing literature.
- A case study highlights a 63-year-old woman who presented with pelvic pain and was found to have a 10 cm tumor in the recto-vaginal septum, which was surgically removed, leading to a diagnosis of cystadenocarcinoma.
- The patient underwent adjuvant chemotherapy and has shown no signs of cancer recurrence after 36 months, suggesting that en bloc resection may improve outcomes by preventing further spread.
[Oncofertility program at the Montpellier university hospital 2 years after].
J Gynecol Obstet Biol Reprod (Paris)
June 2015
Objective: Female fertility preservation in the context of cancer management is crucial for patient's health care. The aim of this study was to evaluate the oncofertility practice at our university hospital of Montpellier since 2011.
Patients And Methods: The evaluation of management of young patients referred to Montpellier University Hospital from September 2011 to September 2013 for oncofertility counselling before cancer treatment.
[Circulating tumor cells: cornerstone of personalized medicine].
J Gynecol Obstet Biol Reprod (Paris)
November 2014
Cancer treatment has evolved toward personalized medicine. It is mandatory for clinicians to ascertain tumor biological features in order to optimize patients' treatment. Identification and characterization of circulating tumor cells demonstrated a prognostic value in many solid tumors.
View Article and Find Full Text PDFAims: We compared histological patterns after lumpectomy for non-palpable breast cancers preoperatively localized by radioguided occult lesion localization plus sentinel node localization (SNOLL) versus wire-guided localization.
Methods: To ensure a homogeneously treated cohort and rigorous comparisons, only patients with invasive cancer and measurable opacity by imaging were included. Exclusion criteria were one or more parameters that could interfere with localization and/or the surgical procedure.
[Anal sphincter injury during operative vaginal delivery using spatulas. What are the risk factors?].
J Gynecol Obstet Biol Reprod (Paris)
February 2012
Objective: To assess risk factors for anal sphincter injury during operative vaginal delivery using spatulas.
Patients And Methods: A monocentric retrospective study of all assisted vaginal deliveries using Thierry and Teissier's spatulas between January 1st, 2008 and December 31st, 2009 in a teaching level III maternity. We studied risk factors such as primiparity, gestational age, maternal age, previous perineal laceration, level and type of presentation, type of expulsion, unsuccessful extraction and successive use of tools, episiotomy, type of anaesthesia and birth weight.