A zinc ferrite nanodrug carrier for delivery of docetaxel: synthesis, characterization, and tests on C6 glioma cells.

Aim: Docetaxel (DTX) loaded bio-compatible PLGA-PEG encapsulated zinc ferrite nanoparticles (ZFNP) formulation was developed and evaluated against C6 glioma cells.

Methods: The ZFNP were characterised using XRD, FE-SEM, TEM, etc. A series of drug formulations were fabricated by conjugating hydrothermally synthesised ZFNP with DTX in a PLGA-PEG matrix and optimised for drug loading.

Anticancer potential of docetaxel-loaded cobalt ferrite nanocarrier: an in vitro study on MCF-7 and MDA-MB-231 cell lines.

Aim: To develop a biocompatible cobalt ferrite (CF-NP) nanodrug formulation using oleic acid and poly (d,l-lactide--glycolic) acid (PLGA) for the delivery of docetaxel (DTX) specifically to breast cancer cells.

Methods: The CF-NP were synthesised by hydrothermal method and conjugated with DTX in a PLGA matrix and were systematically characterised using XRD, FE-SEM, TEM, DLS, FTIR, TGA, SQUID etc. The drug loading, in vitro drug release, cellular uptake, cytotoxicity were evaluated and haemolytic effect was studied.

Reprogramming, oscillations and transdifferentiation in epigenetic landscapes.

Waddington's epigenetic landscape provides a phenomenological understanding of the cell differentiation pathways from the pluripotent to mature lineage-committed cell lines. In light of recent successes in the reverse programming process there has been significant interest in quantifying the underlying landscape picture through the mathematics of gene regulatory networks. We investigate the role of time delays arising from multi-step chemical reactions and epigenetic rearrangement on the cell differentiation landscape for a realistic two-gene regulatory network, consisting of self-promoting and mutually inhibiting genes.

Demographic and clinical profile of patients with brain metastases: A retrospective study.

Context: Brain metastases are the most common type of intracranial neoplasm, with the total number outnumbering primary brain tumors by a ratio of 10:1 and occur in about 25% of cancer patients. However, controversies exist regarding demographic and clinical profile of brain metastases.

Aims: The purpose of this study was to analyze retrospectively the demographic and clinical profile of patients with brain metastases.

Follicular Dendritic Cell Sarcoma of Ileoceacal Region in a Young Woman: A Rare Case Report with Review of Literature.

Follicular dendritic cell sarcoma arises from the follicular dendritic cells present in the lymph nodes, especially of the head and neck area. Rarely, extranodal sites may be affected including tonsil, the oral cavity, liver, spleen and the gastrointestinal tract. Here, we report a case of intra-abdominal follicular dendritic cell sarcoma presenting as a huge mass in the ileocecal region of a 24-year young woman.

Fibrillation of egg white ovalbumin: a pathway via biomineralization.

Here we report the fibrillation of egg white ovalbumin (OVA) induced by the biomineralization of two alkali halides (KCl, NaCl) in the Langmuir-Blodgett (LB) film of OVA. The pressure-area isotherm of OVA shows the salt-induced increment of apparent area/monomer of OVA. Fibrillation of OVA in the LB film is monitored by FE-SEM imaging.

Influence of KCl on the interfacial activity and conformation of hemoglobin studied by Langmuir-Blodgett technique.

We report here the influence of KCl on the interfacial surface activity and conformation of human adult hemoglobin (Hb) using Langmuir and Langmuir-Blodgett (LB) techniques. The studies were done in absence and in presence of KCl salt in the subphase. We have studied the surface pressure-area (π-A) isotherm and surface pressure-time (π-t) kinetics of Hb with the variation of KCl concentrations (C(KCl)).

On the origin of iron-oxide nanoparticle formation using phospholipid membrane template.

In this report, we have studied the formation of iron-oxide nanoparticle at biologically relevant phospholipids, DPPC Langmuir monolayer at air/water interface. Water subphase contains FeCl(3). Adsorption and agglomeration of Fe(3+) ions at DPPC head group have being monitored by Langmuir and Langmuir Blodgett (LB) technique.

Hemoglobin-silver interaction and bioconjugate formation: a spectroscopic study.

In this article, we report the results of the extent of interaction as well as the formation of a bioconjugate of human hemoglobin (Hb) with silver (Ag). The complexation process and conformational changes are characterized using different spectroscopic and microscopic techniques. The UV-vis study demonstrates the perturbation of the soret/heme band and generates conformational heterogeneity within the heme group in the presence of silver.

pH induced structural modulation and interfacial activity of hemoglobin at the air/water interface.

In this Article, we report the surface activity of the human globular blood protein, hemoglobin (Hb), at the air/water interface. The Langmuir-Blodgett technique is used for monolayer characterization. The adsorption growth-kinetics study shows that the adsorption process at the air/water interface is involved with two mechanisms: one diffusion with adsorption and the other rearrangement with unfolding.