Publications by authors named "Ratajova Eva"
Article Synopsis
- - A somatic mutation in the HLA-B gene was identified in a Czech patient with various blood disorders, transitioning from severe aplastic anemia to acute myeloid leukemia.
- - The mutation alters a specific amino acid in the HLA-B protein, potentially impacting its structure and expression.
- - It is hypothesized that this mutation may have developed due to immune selection pressures responding to the leukemia.
Distribution of HLA-DQB1 in Czech Patients with Central Hypersomnias.
Arch Immunol Ther Exp (Warsz)
December 2016
The aim of our study was to analyze the distribution of HLA-DQB1 in Czech patients with central hypersomnias and differences between diagnostic groups of narcolepsy type 1 (NT1), type 2 (NT2), idiopathic hypersomnia (IH) and no central hypersomnia subjects (no-CH). Statistical analysis of DQB1 genotyping was performed on the cohort of 716 patients (375 men, 341 women) with reported excessive daytime sleepiness. DQB1*06:02 allele was present in 94% of the NT1 patients.
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