Vaccination of cattle against tropical theileriosis in Uzbekistan using autochthonous live vaccine.

In Uzbekistan, 1984 cattle were vaccinated with the TAU-219 autochthonous live Theileria annulata vaccine under field conditions. There were no post-vaccination reactions recorded in calves vaccinated with 10 times the recommended dose, under semi-field conditions. After vaccination 53.

Ticks status in Central Asia with a special emphasis on Uzbekistan.

Uzbekistan is located between the greatest rivers of Central Asia and shares borders with Kazakhstan to the west and to the north, Kyrgyzstan and Tajikistan to the east, and Afghanistan and Turkmenistan to the south. The climate is severely continental and arid, with hot summers and cold winters. These climatic particularities of Uzbekistan determine the distribution of tick fauna.

Babesia bigemina: attenuation of an Uzbek isolate for immunization of cattle with live calf- or culture-derived parasites.

The virulence of an Uzbek isolate of Babesia bigemina, obtained from infected Boophilus annulatus ticks from an endemic area in Uzbekistan, was attenuated for immunization of cattle with autochthonous calf- or culture-derived parasites in Uzbekistan. After four "slow passages" in vivo the virulence was reduced, as evidenced by the response of calves inoculated with an experimental live frozen vaccine produced from the following passage. The vaccine was safe and protective against homologous virulent challenge under laboratory conditions.

Proteolytic enzyme activity and attenuation of virulence in Theileria annulata schizont-infected cells.

A field isolate of Theileria annulata (Uzbek strain) was obtained from calves infected by Hyalomma anatolicum ticks collected from an endemic region in Uzbekistan. Schizont-infected bovine cells that had been established and propagated in cell culture were examined for attenuation both in vivo, by inoculating cells from various passages into calves, and in vitro for metalloproteinase activity. During serial subcultivation a gradual reduction in virulence and in enzyme activity in cells infected with the Uzbek strain were observed.

[Population genetics research in the Lerik region of Azerbaijan].

The results of populational, clinic-genealogical and genetic-demographic research for six villages in Lerik region of Azerbaijan Republic are presented. The frequency of consanguineous marriages according to pedigrees was 62.3% with 32.

Thalassaemia in Azerbaijan.

beta thalassaemia is present throughout the southern regions of the former USSR. We have defined the clinical picture of the disorder, the spectrum of beta thalassaemia mutations, and the role of customary consanguineous marriage in Azerbaijan, where thalassaemia presents a public health problem of the same order as that in Greece. Contrary to earlier suggestions, we found that the common form of the disorder is typically severe.

[Atrioplasty in surgical correction of mitral valve defect complicated by left-sided atriomegaly].

Surgical treatment of 40 patients with mitral valvular diseases and left atriomegaly is analysed. The dimensions of the giant left atrium in this group of patients must be reduced because it causes compression of the posterobasal part of the left ventricle, constriction of the lumen of the left main bronchus or compression of the inferior and middle lobes of the right lung. Left atrioplasty has a favorable effect on the course of the immediate postoperative period and reduces significantly hospital mortality among this grave contingent of patients.

[Cardiac insufficiency and mortality after correction of the mitral valve defect, depending on the degree of cardiac output before the operation].

The course of the postoperative period was studied in 107 patients subjected to adequate correction of mitral valvular disease; 88 of them underwent open heart surgery. The cardiac output was measured by radiocardiography. Total postoperative mortality was 13%, cardiac insufficiency mortality 8.