Graphene quantum dot cross-linked carboxymethyl cellulose nanocomposite hydrogel for pH-sensitive oral anticancer drug delivery with potential bioimaging properties.

Herein, graphene quantum dots (GQDs) were introduced as a novel and safe crosslinker for carboxymethyl cellulose to make biodegradable and biocompatible hydrogels. The casting was used as a simple method for the preparation of the CMC/GQDs films. Effects of the GQDs percentage on the physicochemical properties of the films were studied, and several characterizations were performed including Fourier transform infrared spectroscopy, UV-vis spectroscopy, scanning electron microscopy, gas permeability, and mechanical testing analysis.

Cu-crosslinked carboxymethylcellulose/naproxen/graphene quantum dot nanocomposite hydrogel beads for naproxen oral delivery.

In this work, copper acetate was used as a new physical crosslinker to prepare carboxymethylcellulose (CMC) based hydrogel nanocomposite beads. Due to the characteristics of the prepared CMC-based hydrogel nanocomposite beads such as mildness, simplicity, and the creation of small and uniform shapes, the presented procedure could attract great consideration in the field of controlled release of drugs. Naproxen (NPX) as a model drug was pre-loaded during the preparation of hydrogel beads.

Chitin/silk fibroin/TiO bio-nanocomposite as a biocompatible wound dressing bandage with strong antimicrobial activity.

Interconnected microporous biodegradable and biocompatible chitin/silk fibroin/TiO nanocomposite wound dressing with high antibacterial, blood clotting and mechanical strength properties were synthesized using freeze-drying method. The prepared nanocomposite dressings were characterized using SEM, FTIR, and XRD analysis. The prepared nanocomposite dressings showed high porosity above 90% with well-defined interconnected porous construction.

A potential bioactive wound dressing based on carboxymethyl cellulose/ZnO impregnated MCM-41 nanocomposite hydrogel.

Lack of antibacterial activity, deficient water vapor and oxygen permeability, and insufficient mechanical properties are disadvantages of existing wound dressings. Hydrogels could absorb wound exudates due to their strong swelling ratio and give a cooling sensation and a wet environment. To overcome these shortcomings, flexible nanocomposite hydrogel films was prepared through combination of zinc oxide impregnated mesoporous silica (ZnO-MCM-41) as a nano drug carrier with carboxymethyl cellulose (CMC) hydrogel.

Antibiotic loaded carboxymethylcellulose/MCM-41 nanocomposite hydrogel films as potential wound dressing.

Existing wound dressings have disadvantages such as lack of antibacterial activity, insufficient oxygen and water vapor permeability, and poor mechanical properties. Hydrogel-based wound dressings swell several times their dry volume and would be helpful to absorb wound exudates and afford a cooling sensation and a moisture environment. To overcome these hassles, a novel antibiotic-eluting nanocomposite hydrogel was designed via incorporation of mesoporous silica MCM-41 as a nano drug carrier into carboxymethylcellulose hydrogel.