Publications by authors named "Rasul Khasanov"
Despite limited research, existing studies using generic quality of life (QOL) tools indicate decreased physical health and compromised emotional functioning in children with IF. This study investigates QOL in children with short bowel syndrome (SBS) and its determinants. The study included 57 pediatric patients with SBS treated at Mannheim's University Hospital between 1998 and 2014.
View Article and Find Full Text PDFCell replacement in aganglionic intestines is a promising, yet merely experimental tool for the therapy of congenital dysganglionosis of the enteric nervous system like Hirschsprung disease. While the injection of single cells or neurospheres to a defined and very restricted location is trivial, the translation to the clinical application, where large aganglionic or hypoganglionic areas need to be colonized (hundreds of square centimetres), afford a homogeneous distribution of multiple neurospheres all over the affected tissue areas. Reaching the entire aganglionic area is critical for the restoration of peristaltic function.
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- - Short bowel syndrome (SBS) is a serious condition leading to intestinal failure in children, and researchers studied the changes in muscle layers and the myenteric plexus in the small intestine after inducing SBS in rats.
- - The study involved comparing 12 rats with SBS to 10 rats that underwent sham surgery, and human samples were also collected from patients who had small bowel resections.
- - Results showed significant muscle tissue growth (hypertrophy) in the intestines of SBS-affected rats and increased expression of nestin, indicating higher neuronal plasticity, which suggests a close relationship between the enteric nervous system and intestinal adaptation mechanisms.
Impairment of both the central and peripheral nervous system is a major cause of mortality and disability. It varies from an affection of the brain to various types of enteric dysganglionosis. Congenital enteric dysganglionosis is characterized by the local absence of intrinsic innervation due to deficits in either migration, proliferation or differentiation of neural stem cells.
View Article and Find Full Text PDFObjective: Hirschsprung's disease (HSCR) is a congenital intestinal neurodevelopmental disorder characterized by the absence of enteric ganglion cells in the distal colon. Although Hirschsprung-associated enterocolitis (HAEC) is the most frequent life-threatening complication in HSCR, to date reliable biomarkers predicting the likelihood of HAEC are yet to be established. We established a three-center retrospective study including 104 HSCR patients surgically treated between 1998 and 2019.
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- Enterocolitis is a major complication of Hirschsprung disease (HD) that can lead to toxic megacolon (TM), a severe condition particularly dangerous for infants with undiagnosed HD.
- A study reviewed the cases of 4 infants with TM, all of whom presented with symptoms like abdominal pain, distension, and diarrhea, and were diagnosed through clinical evaluation and imaging.
- Results indicated that conservative treatment was ineffective, leading to surgical interventions; unfortunately, 2 out of 3 patients treated with an ileostomy died, whereas one who underwent additional resection of the colon survived without complications.