Publications by authors named "Rasoul Sadegh"
Article Synopsis
- Methotrexate (MTX) is a chemotherapy drug that can cause kidney damage at high doses, but glucarpidase, produced by engineered E. coli, helps mitigate this issue.
- The study aimed to identify suitable signal peptides (SPs) for secreting glucarpidase from E. coli using bioinformatics tools.
- Results showed that two specific SPs, PPB and TIBA, can effectively translocate glucarpidase outside the cell, although further experimental validation is needed to confirm these findings.
Statement Of The Problem: Quercetin is a pharmacological flavonoid that can inhibit high mobility group box1 (HMGB1) protein, a non-histone nuclear protein that is implicated in inflammation. Th17 cells are important cells in the pathogenesis of inflammation. Pulpitis is the inflammation of dental pulp, which usually is accompanied by pain.
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