The emerging role of S100A4 and S100A14 proteins in colorectal cancer progression.

Colorectal cancer (CRC) is the third most frequent type of cancer and the second leading cause of cancer-related deaths globally. Despite a thorough understanding of its biology, etiology, and epidemiology, an estimated 1.8 million new cases are diagnosed each year, and 900000 people die as a result of malignancy.

Investigating Serum Cortisol Dynamics and Cardiovascular Impacts Amid University Exam Stress: A Pre-Post Cohort Study.

Objective: Our objective was to investigate the perceived stress levels among pharmacy students enrolled at the University of Duhok both prior to and following examination periods, with a concurrent assessment of potential cardiovascular effects.

Methods: The study included 49 participants from the College of Pharmacy at the University of Duhok and utilized a pre-post cohort design. High-stress pre-examination assessments were scheduled at 8:30 AM on the day of the examination, and low-stress post-examination assessments were also conducted at 8:30 AM over a two-week period without academic examinations.

In vitro pharmacological evaluation of Methanolic leaf extract of for antifungal and anti-breast cancer activities.

Background: Medicinal plants remained the primary choice worldwide from several centuries due to many therapeutic effects in the management of infectious and non-infectious diseases. Therefore, exploration of new medicinalplants as a green medicine has the major concern of many research groups. Microbial infections and different types of cancers in human are among the common health problems both in developing as well as in developed countries.

Prevention and potential remedies for antibiotic resistance: current research and future prospects.

The increasing threat of antibiotic resistance and shrinking treatment options for infections have pushed mankind into a difficult position. The looming threat of the return of the pre-antibiotic era has caused a sense of urgency to protect and conserve the potency of antibiotic therapy. One of the perverse effects of antibiotic resistance is the dissemination of its causative agents from non-clinically important strains to clinically important strains and vice versa.

Submandibular Gland Preservation in Oral Cavity Squamous Cell Carcinomas: Our Analysis at A Tertiary Care Hospital.

Introduction: Surgical excision forms the principal treatment of oral cavity squamous cell carcinomas. The comprehensive surgical management consists of Wide Local Excision of the tumor and Neck Dissection with removal of Submandibular gland. The submandibular gland accounts for 70-90 % of unstimulated salivary volume.

Designing electrolytes with high solubility of sulfides/disulfides for high-energy-density and low-cost K-Na/S batteries.

Alkaline metal sulfur (AMS) batteries offer a promising solution for grid-level energy storage due to their low cost and long cycle life. However, the formation of solid compounds such as MS and MS (M = Na, K) during cycling limits their performance. Here we unveil intermediate-temperature K-Na/S batteries utilizing advanced electrolytes that dissolve all polysulfides and sulfides (KS, x = 1-8), significantly enhancing reaction kinetics, specific capacity, and energy density.

Correction: Suleman et al. Immunoinformatics and Immunogenetics-Based Design of Immunogenic Peptides Vaccine against the Emerging Tick-Borne Encephalitis Virus (TBEV) and Its Validation through In Silico Cloning and Immune Simulation. 2021, , 1210.

The authors would like to make the following correction to this published paper [...

The Impact of Vaccination Status on Anthropometric Indices of Growth Among Children: A Cross-Sectional Study.

Background Childhood immunization programs in underdeveloped nations can improve children's growth and nutritional status and prevent growth delays while protecting against infectious diseases and meeting growth norms. This study aimed to assess the impact of vaccination status on the anthropometric indices of children aged 12-18 months at an Expanded Programme on Immunization vaccination center and compare the anthropometric indices of growth in children with complete and incomplete vaccination statuses. Methodology This study was conducted at the rural health center in Kala Shah Kaku, Pakistan, from November 2023 to December 2023.

In silico design of multi-epitope vaccines against the hantaviruses by integrated structural vaccinology and molecular modeling approaches.

Hantaviruses are single-stranded RNA viruses belonging to the family Bunyaviridae that causes hantavirus cardiopulmonary syndrome (HCPS) and hemorrhagic fever with renal syndrome (HFRS) worldwide. Currently, there is no effective vaccination or therapy available for the treatment of hantavirus, hence there is a dire need for research to formulate therapeutics for the disease. Computational vaccine designing is currently a highly accurate, time and cost-effective approach for designing effective vaccines against different diseases.

Understanding the carbendazim adsorption from water using biochar derived from apple pomace and industrial wastewater sludge: experimental and DFT approaches.

Biochars derived from apple pomace (AP-BC) and industrial wastewater sludge (IS-BC) were used to investigate adsorption performance and mechanism for removing carbendazim from water and compare its performance with commercial biochar (commercial BC). The results showed that the adsorption capacity of AP-BC and IS-BC were 76 mg g and 82 mg g respectively that was comparable with the commercial BC (80 mg g). The adsorption kinetics and isotherms were best described by the Pseudo-second-order and Langmuir models.

Microbial Nanotechnology for Precision Nanobiosynthesis: Innovations, Current Opportunities and Future Perspectives for Industrial Sustainability.

A new area of biotechnology is nanotechnology. Nanotechnology is an emerging field that aims to develope various substances with nano-dimensions that have utilization in the various sectors of pharmaceuticals, bio prospecting, human activities and biomedical applications. An essential stage in the development of nanotechnology is the creation of nanoparticles.

Enzyme regulation patterns in fungal inoculated wheat may reflect resistance and tolerance towards an insect herbivore.

Seed inoculation with entomopathogenic fungi (EPF) causes plant-mediated effects against arthropod herbivores, but the responses vary among EPF isolates. We used a wheat model system with three isolates representing Beauveria bassiana and Metarhizium spp. causing either negative or positive effects against the aphid Rhopalosiphum padi.

Relationship between secondary metabolites and insect loads in cabbage with different leaf shapes and positions.

Introduction: Secondary metabolites in plants play a crucial role in defense mechanisms against insects, pests, and pathogens. These metabolites exhibit varying distributions within and among plant parts under different biotic and abiotic conditions. Understanding the intricate relationships between secondary metabolites and insect populations can be helpful for elucidating plant defense mechanisms and enhancing agricultural managing efficiencies.

Preliminary assessment of microplastic in rhizosphere and non-rhizosphere region of mangrove at four locations along Karachi coast, Pakistan.

Mangrove ecosystem faces significant threats from the various pollutants including microplastic (MPs). The aim of this study was to assess variations in MP distribution in mangrove sediments of rhizosphere (R) and non-rhizosphere (NR) regions. A total of 14,960 MP particles were identified from Sandspit backwater (SS-1 & SS-2) and Creek areas (PQ & KC).

Thriving under Salinity: Growth, Ecophysiology and Proteomic Insights into the Tolerance Mechanisms of Obligate Halophyte .

Studies on obligate halophytes combining eco-physiological techniques and proteomic analysis are crucial for understanding salinity tolerance mechanisms but are limited. We thus examined growth, water relations, ion homeostasis, photosynthesis, oxidative stress mitigation and proteomic responses of an obligate halophyte to increasing salinity under semi-hydroponic culture. Most biomass parameters increased under moderate (300 mmol L of NaCl) salinity, while high (900 mmol L of NaCl) salinity caused some reduction in biomass parameters.

Correction to "Mitigation of Salinity Stress and Lead Toxicity in Maize by Exogenous Application of the Sorghum Water Extract".

[This corrects the article DOI: 10.1021/acsomega.3c09495.

Process evaluation of a pragmatic feasibility trial on smokeless tobacco cessation intervention delivered in dental hospitals.

Background: Article 14 of the WHO 'Framework Convention on Tobacco Control' recommends, that all oral healthcare providers provide support for tobacco cessation, to all patients. Despite evidence on the effectiveness of tobacco cessation interventions in dental settings, implementation remains low in most high-burden countries like Pakistan. A pragmatic pilot trial of a dentist-delivered behavioural support intervention for smokeless tobacco (ST) cessation, was conducted in dental hospitals in Pakistan.

Determining the cost of acute stroke care for a single stay at a tertiary care centre in Pakistan.

Objective: To assess the economic burden of acute stroke, and to determine the average cost of acute stroke care for a single hospital stay in a public tertiary care hospital.

Methods: The cross-sectional study was conducted at the Medical Teaching Institute, Bacha Khan Medical Complex, Swabi, Pakistan, from May 16 to September 19, 2022, and comprised patients of either gender who were hospitalised with an acute stroke for the first time. All costs incurred during the care of the patients were measured using the micro-costing methodology, and the association of the cost with other variables was evaluated.

In-vitro and in-vivo antidiabetic activity of aerial parts of Aitchisonia rosea supported by phytochemical and GC-MS analysis.

Medicinal plants contain a wide variety of bioactive phytoconstituents which can serve as new therapeutic agents for several diseases. This study examines the antidiabetic potential of Aitchisonia rosea in alloxan-induced diabetic rats and identifies its bioactive phytoconstituents using GC-MS. In vitro, antidiabetic potential was established using the α-amylase inhibition assay.