No significant influence of OCT1 genotypes on the pharmacokinetics of morphine in adult surgical patients.

We investigated the impact of genetic variants in OCT1 (SLC22A1) on morphine, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) pharmacokinetics in adult patients scheduled for major surgery. Blood samples were taken before and 5, 10, 15, 30, 45, 60 and 90 min after a bolus of morphine (0.15 mg/kg).

[Clonidine can reduce opioid medication during post-operative pain].

Post-operative pain management can be a challenge, and one of the first choices seems to be opioids. However, opioids have undesirable side effects, and attention may lead to a multimodal analgesia. The use of clonidine is a part of this strategy.

[Antidigitalis Fab-fragment for treating poisoning from a foxglove plant].

Plant poisonings are rare in Denmark, but can have fatal consequences. We present a case in which a woman went into cardiac arrest after having ingested leaves from the foxglove plant. Sinus rhythm was not restored until Digibind was administered.

[A possible analgesic effect of nicotine on postoperative pain].

Since postoperative pain often is undermanaged, and opioids, although being efficient analgesics, have undesirable side effects, attention has turned towards adjuvant therapies, among them nicotine. We present seven studies of which six show an effect of nicotine on postoperative pain when given in a low dose, with short time of exposure and to non-smokers. Other possible confounders are gender and type of anaesthesia.

[Who are the users of emergency contraception?].

Introduction: A user profile is necessary in order to direct future campaigns for emergency contraception (EC).

Material And Methods: Over a three-month period, 423 women with prescriptions for EC were consecutively entered in the study, which was carried out in four inner-city pharmacies in Copenhagen, Denmark.

Results: The median age was 24 years (range 13-50 years).