The selective effect of N-feruloylserotonins isolated from Leuzea carthamoides on nociception and anxiety in rats.

The effects of N-feruloylserotonins, substances isolated from the seeds of Leuzea carthamoides (WILLD.) DC., on nociception and anxiety were studied in Wistar rats.

Surprises and omissions in toxicology.

The paper describes expected and unexpected results gained from studies performed decades ago, and so to say - forgotten. 1. Different bacterial toxins can induce considerable changes in pharmacokinetics and pharmacodynamics of applied drugs.

Anticipation of acute stress in isoprenaline-sensitive and - resistant rats: strain and gender differences.

The effect of stress anticipation was studied in two inbred Wistar rat strains with high and low sensitivity to isoprenaline. The animals were exposed to tail-flick and 4-hr water immersion restraint stress on two consecutive days. On the first day stress was applied to one group and the next day to the anticipation group.

The influence of repeated prestressors on single stress response in rats.

The effect of various stressors of different intensity applied in random order before the final single immersion restraint stress was tested in two inbred rat strains, isoprenaline-sensitive and isoprenaline-resistant. The isoprenaline-sensitive strain revealed higher incidence of heart lesions after this single acute stress and low incidence of gastric lesions. The isoprenaline-resistant strain had the opposite characteristics.

Behavioral characteristics of two rat strains differing in sensitivity to the cardiotoxic effect of isoprenaline.

Behavioral pattern was studied in two inbred strains of rats which have different responses to stress. These strains were originally developed from a randomly bred Wistar rat colony, according to high or low myocardial cells sensitivity to cardiotoxic effect of isoprenaline. One strain is very sensitive to isoprenaline cardiotoxicity (IS = isoprenaline sensitive) the other strain is more resistant (IR = isoprenaline resistant).

[Differences in the behavior of organic lesions, immunologic and metabolic parameters in 2 inbred strains of rats].

Two inbred rat strains were obtained by selective breeding and inbreeding: IR (isoprenaline resistant) and IS (isoprenaline sensitive). In addition to known differences between the two strains (1) other differences were found. As compared to IS strain, IR rats were more aggressive and showed more comfort behaviour in open field test.

Different stressors and blood lipid peroxidation.

Elevation of lipid peroxidation (LOX) was observed in rabbits and mice after the intravenous administration of 0.2 micrograms.kg-1 of lipopolysaccharide (LPS) and 100 micrograms.

Vibration stress and pharmacokinetics of rifampicin.

The influence of horizontal vibration stress on pharmacokinetics of rifampicin (RFP) 20 mg.kg-1 on rabbits was investigated. RFP was given orally or intravenously.

The effects of peptidoglycan, a pyrogenic constituent of gram-positive microorganisms, on the pharmacokinetics of rifampicin.

Pharmacokinetics of rifampicin (20 mg/kg orally or i.v.) was determined in calves and rabbits.

Bacterial pyrogens of different origin and pharmacokinetics of rifampicin.

Changes of pharmacokinetics of rifampicin (RFP, Rifadin were investigated on endotoxin pretreated still not ruminant calves. The animals served as their own controls and drug administration twice in a 1-week interval gave the same results. Endotoxin 0.

Changes of pharmacokinetics of trimethoprim after pretreatment with streptococcal peptidoglycan.

Trimethoprim (TMP) 10 mg.kg-1 was given orally to calves and rabbits. Two to three weeks later the animals were pretreated by i.

[Efficacy of levimasole and nilverm on gastrointestinal nematodes in cattle and their effect on milk yield].

Effect of Levamisole and Nilverm on gastrointestinal nematodes in cattle and on the milk yield. The effect of Levamisole--pure substance and the preparation Nilverm on the milk yield of cattle was experimentally tested, however, significant positive results were not recorded. Following Nilverm application and after the experiments had been terminated, t-test showed significant daily decrease (2.

The effect of intermittent treatment with sulphadimidine on coccidiosis in preruminant calves.

Preruminant calves excreted coccidia oocysts in their faeces after 3 weeks of group housing. Two weeks of oral sulphadimidine (SDM) administration, 50 mg/kg on the first day of treatment followed by daily administration of 37.5 mg/kg, under the same housing conditions kept the faeces free of oocysts.

Endotoxin and pharmacokinetics of rifampicin.

Changes of pharmacokinetics of rifampicin (20 mg . kg-1 orally) were seen in rabbits pretreated with 0.02, 0.

Coccidiosis in preruminating calves the effect of management and short-term treatment on the spread of infection and reinfection.

In farms with large numbers of individually-housed calves, the spread of coccidia is slow. In group pens, however, all the calves became infected within 3-4 weeks of being housed together. At the beginning of group housing no oocysts were found in the faeces of any of the calves.