Publications by authors named "Rasim Selimoglu"
The emergence and evolutionary expansion of gene families implicated in cancers and other severe genetic diseases is an evolutionary oddity from a natural selection perspective. Here, we show that gene families prone to deleterious mutations in the human genome have been preferentially expanded by the retention of "ohnolog" genes from two rounds of whole-genome duplication (WGD) dating back from the onset of jawed vertebrates. We further demonstrate that the retention of many ohnologs suspected to be dosage balanced is in fact indirectly mediated by their susceptibility to deleterious mutations.
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- The Ras family G-proteins RalA and RalB play essential but distinct roles in cancer development by helping cells overcome normal limits on growth and survival.
- RalA is responsible for attaching the exocyst to the cytokinetic furrow during the early stages of cell division, while RalB is needed later at the midbody to facilitate the final separation of daughter cells.
- Together, RalA and RalB coordinate the exocyst's functions in mitosis by responding to various regulatory signals, highlighting their importance in managing cell division effectively.