Publications by authors named "Rashwita Gyanwali"
spp. mosquitoes are important vectors of viruses, such as West Nile virus, Eastern equine encephalitis virus and Rift valley fever virus. However, their interactions with innate antiviral immunity, especially RNA interference (RNAi), are not well known.
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- Arboviruses transmitted by mosquitoes contribute to millions of deaths annually, while recent discoveries have identified many insect-specific viruses (ISVs) in these mosquitoes that cannot infect vertebrates.
- This study focused on Agua Salud alphavirus (ASALV), an insect-specific alphavirus, and its interaction with the mosquito's RNA interference (RNAi) antiviral response, revealing that the knockdown of certain RNAi proteins enhances ASALV replication.
- The findings suggest that ASALV's interaction with the RNAi mechanism in mosquitoes has distinct differences from other arthropod-borne alphaviruses, indicating a need for further research on ISVs and their antiviral strategies.