Tackling Multiple-Drug-Resistant Bacteria With Conventional and Complex Phytochemicals.

Emerging antibiotic resistance in bacteria endorses the failure of existing drugs with chronic illness, complicated treatment, and ever-increasing expenditures. Bacteria acquire the nature to adapt to starving conditions, abiotic stress, antibiotics, and our immune defense mechanism due to its swift evolution. The intense and inappropriate use of antibiotics has led to the development of multidrug-resistant (MDR) strains of bacteria.

Improvement in vitamin B status of Wistar rats by supplementing the diet with biomass.

The sources of bioavailable vitamin B are limited, and most of them are animal-derived. a freshwater microalga, is known for immune system boosting, nutraceutical properties and presence of a natural form of vitamin B. The present study focused on the in vivo evaluation of the biomass as a source of bioavailable vitamin B to alleviate the vitamin B deficiency status of Wistar rats.

Crystallography, in Silico Studies, and In Vitro Antifungal Studies of 2,4,5 Trisubstituted 1,2,3-Triazole Analogues.

A series of 2,4,5 trisubstituted-1,2,3-triazole analogues have been screened for their antifungal activity against five fungal strains, , , , , and , via a 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) microdilution assay. Compounds GKV10, GKV11, and GKV15 emerged as promising antifungal agents against all the fungal strains used in the current study. One of the highly active antifungal compounds, GKV10, was selected for a single-crystal X-ray diffraction analysis to unequivocally establish its molecular structure, conformation, and to understand the presence of different intermolecular interactions in its crystal lattice.

Improvement of vitamin B status with Spirulina supplementation in Wistar rats validated through functional and circulatory markers.

Spirulina evaluated as a source of vitamin B through the modulation of vitamin B deficiency mediated physiological and biochemical changes in experimental animals. The B deficient male weanling Wistar rats were fed with Spirulina-supplemented diet for 10 weeks. An increase in urinary methylmalonic acid (22.

Green synthesis, characterisation and bioactivity of plant-mediated silver nanoparticles using root extract.

Consistent search of plants for green synthesis of silver nanoparticles (SNPs) is an important arena in Nanomedicine. This study focuses on synthesis of SNPs using bioreduction of silver nitrate (AgNO) by aqueous root extract of . The biosynthesis of SNPs was monitored by UV-vis analysis at absorbance maxima 432 nm.

Representation of Functional Status Concepts from Clinical Documents and Social Media Sources by Standard Terminologies.

Patient-reported functional status is widely recognized as an important patient-centered outcome that adds value to medical care, research, and quality improvement. Functional status outcomes are, however, not routinely or uniformly collected in the medical record, except in certain small patient populations (e.g.

Review on natural coumarin lead compounds for their pharmacological activity.

Coumarin (2H-1-benzopyran-2-one) is a plant-derived natural product known for its pharmacological properties such as anti-inflammatory, anticoagulant, antibacterial, antifungal, antiviral, anticancer, antihypertensive, antitubercular, anticonvulsant, antiadipogenic, antihyperglycemic, antioxidant, and neuroprotective properties. Dietary exposure to benzopyrones is significant as these compounds are found in vegetables, fruits, seeds, nuts, coffee, tea, and wine. In view of the established low toxicity, relative cheapness, presence in the diet, and occurrence in various herbal remedies of coumarins, it appears prudent to evaluate their properties and applications further.

Siderophore mediated uranium sequestration by marine cyanobacterium Synechococcus elongatus BDU 130911.

Four different marine cyanobacterial morphotypes were tested for their efficacy to produce siderophores in Fe minus [Fe(-)], Fe minus Uranium dosed [Fe(-)U(+)], and Fe dosed Uranium dosed [Fe(-)U(+)] media. Of the four organisms tested, Synechococcus elongatus BDU 130911 produced the highest amount of siderophore of 58μgmg(-1) dryweight. The results clearly indicate that uranium induces siderophore production in marine cyanobacteria even in the presence of iron [Fe(-)U(+)] condition.