Publications by authors named "Rashmi Tyagi"
Coronavirus disease-19 (COVID-19) is caused by severe acute respiratory syndrome coronavirus -2 (SARS-CoV-2) and is responsible for a higher degree of morbidity and mortality worldwide. There is a smaller number of approved therapeutics available to target the SARS-CoV-2 virus, and the virus is evolving at a fast pace. So, there is a continuous need for new therapeutics to combat COVID-19.
View Article and Find Full Text PDFThe present study is conducted to find the solution of rising antimicrobial resistance (AMR) in which is a pathogen responsible for fatal systemic infections in human and animals. The enzyme dihydrofolate reductase (DHFR) is found in all organisms. In this study DHFR of (ec-DHFR) and human DHFR (h-DHFR) is targeted by novel chemical entities (NCE) from the Pathogen box of Medicines for Malaria Venture, Switzerland (MMV) using molecular modelling.
View Article and Find Full Text PDFAs a consequence of present status of tuberculosis (TB) it is the obligation to develop novel targets and potential drugs so that rate of drug resistant TB can be declined. Mycobacterium proteasome is considered to be significant target for the purpose of drug designing as it is responsible for resisting the effect of NO (nitric oxide) immune system defence mechanism against the bacterial cells. Small compounds library from Enamine database has already been tested using virtual screening and molecular docking studies.
View Article and Find Full Text PDFArticle Synopsis
- Tuberculosis (TB) has been declared a health emergency due to rising cases of Multidrug-resistant Tuberculosis (MDR-TB), prompting the urgent need for new therapeutic approaches.
- The study focuses on the proteasome as a potential target for treatment, screening a library of 400 compounds and identifying two promising small molecules, MMV019838 and MMV687146, with significant binding energy and growth inhibition of TB bacteria.
- Further analysis shows that these compounds interact strongly with the proteasome without affecting human cells, indicating their potential as effective, novel therapies against TB while addressing drug resistance issues caused by bacterial efflux pumps.
Imidazoline derivatives, a class of novel cationic surfactants are presently gaining importance in global detergent market due to their wide range of applications. These are extensively used mainly as fabric softeners and antistatic agents. The present communication reviews the preparation, reaction scheme, reaction rates and properties of imidazoline derivatives.
View Article and Find Full Text PDFRole of white light in reversing UV-B-mediated effects in the N2-fixing cyanobacterium Anabaena BT2.
J Photochem Photobiol B
October 2003
Article Synopsis
- The study examined how different levels of artificial UV-B light affected the growth, survival, and photosynthesis of the cyanobacterium Anabaena BT2, particularly looking at the role of visible light.
- Exposure to UV-B levels of 0.2 W m(-2) or higher was detrimental, halting growth at 1.0 W m(-2) and causing significant reductions in carbon uptake and RuBISCO activity.
- Results indicated that the combination of UV-B and visible light (especially blue light at 450 nm) allowed for near-normal growth and activity, suggesting Anabaena BT2 has efficient photoreactivation mechanisms to counteract UV-B damage.