Publications by authors named "Rashmi R Maheshwari"
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Synopsis of recent research by authors named "Rashmi R Maheshwari"
- Rashmi R Maheshwari's research primarily focuses on the molecular mechanisms underlying diabetes, particularly type 2 diabetes (T2D) and cystic fibrosis-related diabetes (CFRD), with an emphasis on the role of transcription factors and cellular identity in pancreatic β-cells.
- Findings indicate that reduced expression of the co-regulator TLE1 in T2D is linked to an increase in islet α-cell numbers, suggesting a potential dysregulation in hormone expression related to β-cell function and identity.
- Furthermore, Maheshwari's studies reveal that CFTR is expressed in a small minority of β-cells in the normal adult human pancreas, contributing to the understanding of β-cell dysfunction in CFRD and the morphological changes in islet structure due to CFTR inhibition in murine models.
