Publications by authors named "Rashin Roshanbin"
Circadian period is compensated for repressor protein turnover rates in single cells.
Proc Natl Acad Sci U S A
August 2024
Article Synopsis
- Most mammalian cells possess circadian clocks that regulate the timing of various biological processes, but how they adapt to changes in metabolism is not well understood.* -
- This study utilized single-cell analysis to explore the relationship between circadian rhythms and protein stability without altering genes, focusing on key proteins involved in the circadian clock.* -
- Findings revealed that the duration of circadian rhythms adjusts based on the degradation rates of repressor proteins, with stability influenced by the phase of the circadian cycle, challenging existing theories about these mechanisms.*
Aim: Exercise intolerance is the central symptom in patients with heart failure with preserved ejection fraction. In the present study, we investigated the adrenergic reserve both in vivo and in cardiomyocytes of a murine cardiometabolic HFpEF model.
Methods: 12-week-old male C57BL/6J mice were fed regular chow (control) or a high-fat diet and L-NAME (HFpEF) for 15 weeks.