Publications by authors named "Rashieda J Hatcher"
Article Synopsis
- * The study demonstrates that USP37 can inhibit medulloblastoma growth in mouse models, highlighting its potential as a tumor suppressor in this type of cancer.
- * The repression of USP37 is linked to the silencing transcription factor REST, which works with the histone methyltransferase G9a to modify histone proteins, suggesting that targeting G9a could reactivate USP37 and serve as a therapeutic strategy for certain medulloblastomas.
Pituitary tumor transforming gene 1 (Pttg1) encodes the mammalian securin, which is an inhibitor of separase (a protease required for the separation of sister chromatids in mitosis and meiosis). PTTG1 is overexpressed in a number of human cancers and has been suggested to be an oncogene. However, we found that, in Pttg1-mutant females, the mammary epithelial cells showed increased proliferation and precocious branching morphogenesis.
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