[Epidemiological characterisation of acute and chronic hepatitis B in Uzbekistan].

The epidemiological survey of 126 foci with patients having acute hepatitis B (AHB) and 120 foci with patients having chronic hepatitis B (CHB) was conducted. The observation of the susceptible members of the family showed that a significantly higher level of infection was found in persons having contacts with CHB patients (44.4 +/- 2.

[Clinical course and treatment regimes of Salmonella infection in children].

Salmonella infection in children caused by polyresistant S. typhimurium strains is characterized by a highly severe course with possible complications. In the treatment of young children with salmonellosis the use of the locally manufactured biologically active additive Bektit-M, possessing adsorption capacity, is recommended.

[Cellular immunity and phagocytosis in pregnant patients with viral hepatitis B].

The work deals with the results of the study of cell-mediated immunity factors (T and B lymphocytes, 0 lymphocytes, T helpers, T suppressors) and phagocytosis in pregnant women with viral hepatitis B, depending on the duration of pregnancy and the severity of the disease. The authors suggest that the severe course of viral hepatitis B in pregnant women may be regarded as the consequence of secondary immunodeficiency.

[The clinico-allergic indices of yersiniosis patients].

Eighty patients with yersiniosis (40 with intestinal yersiniosis, 40 with pseudotuberculosis) were examined for clinical and allergic characteristics (collection of allergological histories, identification of the most common allergic symptoms of the disease and determination of the index of mast cell degranulation). According to the data obtained, the patients with yersiniosis are admitted to the hospital with an aggravated premorbid condition in the form of body allergization, in whose origin both hereditary and acquired factors are of importance. The allergic manifestations of the disease are more pronounced in patients with pseudotuberculosis.

[The neutrophil receptor apparatus in typhoid fever].

In 157 typhoid fever patients and 36 practically healthy persons the content of neutrophils forming complement-dependent rosettes (NEAC rosette-forming cells), as well as rosettes with sheep red blood cells (NE rosette-forming cells) and with typhoid erythrocyte diagnosticum (NS rosette-forming cells), has been studied. The data obtained in this investigation indicate that antigen-binding neutrophils play an active functional role in the pathogenesis of typhoid fever at its acute stage. The values characterizing the content of N rosette-forming cells may be used as a criterion for the evaluation of the severity of infection, as well as for the prognostication of complications and relapses.

[Coamide stimulation of immunogenesis during experimental levomycetin therapy].

The effect of various doses of levomycetin on immunogenesis and capacity of coamide for stimulation of immunogenesis in levomycetin therapy was studied. It was found that massive five-fold doses of levomycetin sodium succinate (I and 0.5 g/kg) administered parenterally or orally inhibited immunogenesis, the inhibition being more pronounced on administration of the antibiotic per os.