Nationwide Cross-Sectional Analysis of Mortality Trends in Patients with Sarcoidosis and Non-Ischemic Cardiovascular Disease-The Impact of Gender, Ethnicity, Geographical Location, and COVID-19 Pandemic.

The epidemiological data regarding mortality rates of adults with sarcoidosis and non-ischemic cardiovascular disease (CVD) are limited. A retrospective observational analysis was conducted to identify trends and disparities related to sarcoidosis and non-ischemic cardiovascular disease mortality among the adult US population from 1999 to 2022. We used the Centers for Disease Control and Prevention (CDC) WONDER database to extract death certificate data for the adult US population (≥25 years).

Unlocking the role of miR-17: Driving G1-S cell cycle transition in oral tongue cancer through integrated bioinformatics and laboratory analyses.

Objective: This study aims to identify miRNA-mediated regulation of the cell cycle in oral tongue cancer.

Methods: Comprehensive computational analysis was performed on the GEO dataset "GSE168227". DIANA Tool-mir path v.

COMPARISON OF BACTERIAL PROBIOTICS (BIFIDOBACTERIUM AND LACTOBACILLUS) VERSUS FUNGAL PROBIOTICS (SACCHAROMYCES) IN THE TREATMENT OF ACUTE DIARRHOEA IN CHILDREN AGED 6 MONTHS TO 5 YEARS.

Background: Acute diarrhoea among children mainly due to infection must be treated prophylactically to reduce mortality. The objective of this study was to compare the outcome of using bacterial probiotics (Bifidobacterium and Lactobacillus) versus fungal probiotics (Saccharomyces) for acute diarrhoea among children aged 6 months to 5 years.

Methods: A non-randomized control trial was conducted at diarrhoea ward, the Children's Hospital, Lahore from 1st March 2022 to 1st March 2024.

ASSOCIATION OF CONSANGUINITY WITH RECURRENT FOETAL LOSS.

Background: Approximately 25% of all recognized pregnancies result in foetal loss. Women who will experience two consecutive foetal loss is less than 5%, while loss of three or more consecutive pregnancies in the first trimester, termed as Recurrent foetal loss (RFL), occurs in 1% of all pregnancies. RFL is often associated with cousin marriages.

Designing a multi-epitope construct using immuno-informatic tools to prepare a messenger RNA vaccine against ticks.

Background And Aims: Ticks are blood-feeding ectoparasites that transmit pathogens to animals and humans. One of the most important hard ticks in animals is , which transmits and spp. Although many potential tick vaccine candidates have been identified, no effective vaccine that can provide sterile immunity against tick infestations has been developed.

COMPARISON OF EFFECTIVENESS OF INFERIOR ALVEOLAR NERVE BLOCK AND GOW GATES TECHNIQUE IN MANDIBULAR MOLAR TEETH WITH IRREVERSIBLE PULPITIS.

Background: Local anaesthetics are the most important and most utilized agents in the dental profession today. Achieving effective pain control holds a prime importance for any dental procedure. The most commonly employed technique to achieve effective anaesthesia in mandibular molar teeth with irreversible pulpitis is Inferior Alveolar Nerve Block.

A comparative study of the microbiomes of the ticks Rhipicephalus microplus and Hyalomma anatolicum.

Hyalomma anatolicum and Rhipicephalus microplus are tick species that are important vectors of numerous pathogens affecting both humans and livestock. Endosymbionts, such as Coxiella-like endosymbionts (CLE), Francisella-like endosymbionts (FLE), and Candidatus Midichloria, play a crucial role in the physiology and vector competence of these ticks. In this study, we investigated the microbial composition of H.

Tick Infestation and Molecular Detection of Tick-Borne Pathogens from Indian Long-Eared Hedgehogs () in Pakistan.

Hedgehogs can act as reservoirs for the transmission of tick-borne pathogens (TBPs) to domestic livestock, wild animals, and humans. Understanding host-tick dynamics is essential to evaluate the impact of TBPs. This study was conducted in Pakistan and aimed to determine the prevalence and species of TBPs in the blood and ticks of Indian long-eared hedgehogs captured from various environments.

IRON DEFICIENCY WITHOUT ANAEMIA IN COPD PATIENTS: ASSESSING EXERCISE CAPACITY AND EXACERBATION FREQUENCY.

Background: Chronic Obstructive Pulmonary Disease (COPD) is a global health challenge with significant morbidity and mortality. Iron deficiency, including non-anaemic iron deficiency (NAID), has been identified as a potential comorbid in COPD, affecting patient outcomes and disease severity. This study aimed to investigate the prevalence and impact of iron deficiency on the severity and clinical outcomes in COPD patients.

Association between the variations in metabolic pathways and oral cancer risk: results from a Pakistani case-control study.

Background: Oral cancer (OC) is a significant global health concern, with Pakistan ranking 5th worldwide in OC incidence. Given the poor prognosis, early detection of at-risk individuals is crucial. Genetic factors, particularly single nucleotide polymorphisms (SNPs) in metabolic genes, may influence OC susceptibility.

Straight-to-Test Pathway in Faecal Immunochemical Testing (FIT)-Negative Patients: A Cost-Effective Approach.

Introduction: Colorectal cancer (CRC) is the fourth most common malignancy in the UK and represents a high-volume diagnostic and clinical burden on the National Health Service (NHS). To maximise the use of limited diagnostic resources and increase efficiency, the colorectal services at University Hospitals North Midlands Trust (UHNM) developed the triage-to-test (TTT) service with risk stratification for diagnostic testing in patients with suspected colorectal cancer using faecal immunochemical testing (FIT) result. Our retrospective cohort study looked at the pick-up rate of colorectal cancer (CRC) and non-colorectal cancer (non-CRC) in FIT-negative patients.

Long-Term Efficacy and Safety of Adhesion Prevention Agents in Abdominal and Pelvic Surgeries: A Systematic Review.

This systematic review evaluates the long-term efficacy and safety of adhesion prevention agents in abdominal and pelvic surgeries, synthesizing data from randomized controlled trials and meta-analyses. Adhesions, common postoperative complications, can lead to significant morbidity, including chronic pain, infertility, and bowel obstruction. Various agents, including hyaluronic acid-carboxymethylcellulose films and icodextrin solutions, have been developed to mitigate these risks.

Towards the Development of the Clinical Decision Support System for the Identification of Respiration Diseases via Lung Sound Classification Using 1D-CNN.

Respiratory disorders are commonly regarded as complex disorders to diagnose due to their multi-factorial nature, encompassing the interplay between hereditary variables, comorbidities, environmental exposures, and therapies, among other contributing factors. This study presents a Clinical Decision Support System (CDSS) for the early detection of respiratory disorders using a one-dimensional convolutional neural network (1D-CNN) model. The ICBHI 2017 Breathing Sound Database, which contains samples of different breathing sounds, was used in this research.

Faecal Immunochemical Test (FIT) Value-Based Algorithm to Triage Symptomatic Colorectal Patients: A Retrospective Study From a Tertiary Care Hospital.

Background The aim was to evaluate the diagnostic accuracy of quantitative faecal immunochemical testing (FIT) in diagnosing colorectal cancer in symptomatic patients and using it to prioritize patients for urgent colorectal investigations. Methods A retrospective review was done of all symptomatic, FIT-positive patients referred from primary care to the colorectal clinic as per the National Institute for Health and Care Excellence (NICE) DG30 pathway from November 1, 2021, to February 11, 2022. Patients under 18 years of age were excluded.

Systematic review on buparvaquone resistance associated with non-synonymous mutation in drug binding genes site of Theileria annulate.

Theileria annulata (T. annulata) is intra-erythrocytic protozoan parasite which is more prevalent in tropical and sub-tropical countries. It has a significant economic impact on the productivity of the dairy industry, and buparvaquone is used to treat infected animals in the prevalent regions of the world.

Evaluating land use and climate change impacts on Ravi river flows using GIS and hydrological modeling approach.

The study investigates the interplay of land use dynamics and climate change on the hydrological regime of the Ravi River using a comprehensive approach integrating Geographic Information System (GIS), remote sensing, and hydrological modeling at the catchment scale. Employing the Soil and Water Assessment Tool (SWAT) model, simulations were conducted to evaluate the hydrological response of the Ravi River to both current conditions and projected future scenarios of land use and climate change. This study differs from previous ones by simulating future land use and climate scenarios, offering a solid framework for understanding their impact on river flow dynamics.

The Intersection of Socioeconomic Differences and Sex in the Management and Outcomes of Acute Myocardial Infarction: A Nationwide Cohort Study.

Patients with lower socioeconomic status (SES) have poorer outcomes following acute myocardial infarction (AMI) than patients with higher SES; however, how sex modifies socioeconomic differences is unclear. Using the United Kingdom (UK) Myocardial Ischaemia National Audit Project (MINAP) registry, alongside Office of National Statistics (ONS) mortality data, we analyzed 736,420 AMI patients between 2005 and 2018, stratified by Index of Multiple Deprivation (IMD) score Quintiles (most affluent [Q1] to most deprived [Q5]). There was no significant difference in probability of in-hospital mortality in our adjusted model according to sex.

De novo assembly of sialotranscriptome of Hyalomma anatolicum and insights into expression dynamics in response to Theileria annulata infection.

Hyalomma anatolicum is a tick of significant one-health importance due to its role as a vector for various pathogens affecting humans, animals and the environment, such as Theileria annulata, which causes tropical theileriosis in cattle, leading to severe economic losses. When infected with pathogens like T. annulata, the salivary glands of H.

Development of Rice Mutants with Enhanced Resilience to Drought Stress and Their Evaluation by Lab Assay, Field, and Multivariate Analysis.

Drought is one of the foremost devastating abiotic stresses reported for rice crops. To improve the productivity of rice, diversity is being enlarged by induced mutation using a source of gamma rays. But this type of mutation rarely results in fruitful products because the chances of getting the desired mutant are very low.

Quantitative Soil Characterization for Biochar-Cd Adsorption: Machine Learning Prediction Models for Cd Transformation and Immobilization.

Soil pollution with cadmium (Cd) poses serious health and environmental consequences. The study investigated the incubation of several soil samples and conducted quantitative soil characterization to assess the influence of biochar (BC) on Cd adsorption. The aim was to develop predictive models for Cd concentrations using statistical and modeling approaches dependent on soil characteristics.

Statistical analysis of topological indices in linear phenylenes for predicting physicochemical properties using algorithms.

QSPR mathematically links physicochemical properties with the structure of a molecule. The physicochemical properties of chemical molecules can be predicted using topological indices. It is an effective method for eliminating costly and time-consuming laboratory tests.