Publications by authors named "Rashid Akbari"
Heterotaxy (HTX) is characterized by an abnormality in the organ arrangement along the Left-Right (LR) axis and is caused by the disruption of LR patterning in early development. LR asymmetry is critical for multiple organs. Specifically, proper LR patterning is crucial for cardiac function and is a cause of congenital heart disease (CHD).
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- - Absence seizures are short episodes where individuals experience impaired consciousness and unresponsiveness, and their underlying neuronal mechanisms are not fully understood, though they are observed in both humans and an awake female rat model.
- - In this model, researchers found that there are decreases in overall neuronal firing during seizures, but patterns of activity among individual neurons vary, including initial surges in firing followed by sustained decreases.
- - Notably, changes in brain activity begin 40-60 seconds prior to a seizure, showing a decline in low-frequency brain waves and behavioral activity, while higher-frequency brain activity and neuronal rhythmicity increase, indicating that significant brain state shifts occur before seizures happen.