Serum MiRNA-27a as potential diagnostic nucleic marker for breast cancer.

Background: Accumulating evidence reveals that microRNA 27a (miR 27a) is implicated in the pathogenesis of cancer. However, its diagnostic role in breast cancer (BC) still needs investigation.

Materials And Methods: MiR 27a expression was assessed in serum samples from patients with primary BC ( 100), benign breast lesions ( 30) and control group served as healthy volunteers ( 20) using quantitative real-time PCR.

Role of some circulating MiRNAs on breast cancer diagnosis.

Aberrant expression of miRNAs has a link with tumorgenesis and their deregulation is reported in biological fluids of cancer patients. Authors aimed to investigate the diagnostic role of miRNA-17-5p, miR-155 and miRNA-222 in serum samples from breast cancer patients ( = 80), benign breast patients ( = 40) and healthy individuals ( = 30) using quantitative real-time PCR technique. Median levels of investigated markers revealed significant increase in primary breast cancer followed by benign and control groups.