Novel High-Performance Functionalized and Grafted Bio-Based Chitosan Adsorbents for the Efficient and Selective Removal of Toxic Heavy Metals from Contaminated Water.

Novel functionalized and/or grafted crosslinked chitosan adsorbents were synthesized and used to remove several toxic heavy metal ions such as nickel, lead, chromium, and cadmium ions from contaminated water. The chitosan biopolymer was functionalized by maleic anhydride (CS_MA) acting also as a crosslinking agent. Glutaraldehyde-crosslinked chitosan (CS_GA) grafted with poly(methyl methacrylate) (CS_MMA) was also synthesized.

In the pursuit of novel therapeutic agents: synthesis, anticancer evaluation, and physicochemical insights of novel pyrimidine-based 2-aminobenzothiazole derivatives.

Cancer remains a worldwide healthcare undertaking, demanding continual innovation in anticancer drug development due to frequent drug resistance and adverse effects associated with existing therapies. The benzothiazole compounds, particularly 2-aminobenzothiazole derivatives, have attracted interest for their versatility in generating novel anticancer agents. This study explores the synthesis, and anticancer evaluation of new pyrimidine-based 2-aminobenzothiazole derivatives.

Crystal structure of 4-(benzo[]thia-zol-2-yl)-1,2-dimethyl-1-pyrazol-3(2)-one.

In the title compound, CHNOS, the inter-planar angle between the pyrazole and benzo-thia-zole rings is 3.31 (7)°. In the three-dimensional mol-ecular packing, the carbonyl oxygen acts as acceptor to four C-H donors (with one H⋯O as short as 2.

Crystal structure of 2-{[5-(methyl-sulfan-yl)-4-phenyl-4-1,2,4-triazol-3-yl]meth-yl}benzo[]thia-zole.

In the structure of the title compound, CHNO, the triazole ring exhibits inter-planar angles of 63.86 (2) and 76.96 (2)° with the phenyl and benzo-thia-zole planes, respectively.

Synthesis and crystal structure of -(5-acetyl-4-methyl-pyrimidin-2-yl)benzene-sulfonamide.

-(5-Acetyl-4-methyl-pyrimidin-2-yl)benzene-sulfonamide, CHNOS, was sythesized and characterized by single-crystal X-ray diffraction. In the crystal, π-π inter-actions between the phenyl and pyrimidine groups of neighbouring mol-ecules form mol-ecular chains parallel to [010]. Adjacent mol-ecular chains are linked by N-H⋯N hydrogen-bonding inter-actions between the pyrimidine and amine groups of neighbouring mol-ecules, resulting in a three-dimensional network.

Synthesis, Physicochemical Properties and Molecular Docking of New Benzothiazole Derivatives as Antimicrobial Agents Targeting DHPS Enzyme.

The drug-resistance problem is widely spread and becoming more common in community-acquired and nosocomial strains of bacteria. Therefore, finding new antimicrobial agents remains an important drug target. From this perspective, new derivatives of benzothiazole were synthesized and evaluated for their antimicrobial activity and ability to inhibit the DHPS enzyme.

4-Amino-5-(4-bromo-benzo-yl)-3-(benzo[]thia-zol-2-yl)-2-[(2',3',4',6'-tetra--acetyl-β-d-galacto-pyran-osyl-)sulfanyl]-thio-phene.

In the title compound, CHBrNOS, the benzo-thia-zole and thio-phene ring systems subtend an inter-planar angle of 7.43 (12)°. The NH group forms intra-molecular hydrogen bonds to N and O.

Medicinal Chemistry of Pyrazolopyrimidine Scaffolds Substituted with Different Heterocyclic Nuclei.

Background: Medicinal chemistry of pyrazolopyrimidine scaffolds substituted with different heterocyclic nuclei has attracted great attention due to their wide range of biological activities that have been reported. Pyrazolopyrimidine scaffold is an important privileged heterocycle nucleus in drug discovery.

Methods: All pharmacological activities of pyrazolopyrimidine scaffold have been mentioned, such as anticancer, anti-inflammatory, antihypertensive, antitubercular, antiviral, antibacterial, antifungal, antidiabetic, and anti-obesity agents.

Novel Thiophene Thioglycosides Substituted with the Benzothiazole Moiety: Synthesis, Characterization, Antiviral and Anticancer Evaluations, and NS3/4A and USP7 Enzyme Inhibitions.

Novel derivatives of benzothiazole-2-thiophene -glycoside were synthesized and tested for their antiviral and anticancer potency and NS3/4A and USP7 enzyme inhibitions. The ring system was formed by first synthesizing new derivatives of 5-mercaptothiophene substituted with the benzothiazole moiety, followed by coupling with various halo sugar derivatives. New compounds were tested in vitro for the cytotoxic effect on five types of normal cell lines and for antiviral activity using a plaque reduction assay against CBV4, HSV-1, HCVcc genotype 4 viruses, HAV HM 175, and HAdV7.

Purine analogs: synthesis, evaluation and molecular dynamics of pyrazolopyrimidines based benzothiazole as anticancer and antimicrobial CDK inhibitors.

Cyclin dependent kinases (CDKs) enzymes regulate cell proliferation and transcriptional processes and can be considered as important targets for the development of anticancer and antimicrobial drugs. In this work, novel benzothiazolyl pyrazolopyrimidine carboxamide and benzothiazolyl pyrazolopyrimidine carbonitrile derivatives were synthesized and characterized. The synthetic process was carried out via the reaction of ylidine benzothiazole derivatives with pyrazolocarboxamide and pyrazolocarbonitrile through a Michael addition pathway.

Crystal structure of 2-(benzo[]thia-zol-2-yl)-3,3-bis-(ethyl-sulfan-yl)acrylo-nitrile.

In the title compound, CHNS, the double-bond system of the acrylo-nitrile moiety is significantly non-planar, with absolute torsion angles of 13.9 (2) and 15.1 (2)°.

Purine analogues as potential CDK9 inhibitors: New pyrazolopyrimidines as anti-avian influenza virus.

Cyclin dependent kinases (CDKs) are a group of enzymes involved in different phases of the cell cycle. In addition, it has been reported that CDK9 could be used as a crucial target for the development of antiviral drugs such as purine analogues; roscovitine and dinaciclib. A new series of benzothiazolyl pyrazolopyrimidine carboxamide derivatives were synthesized and evaluated for their antiviral activity against avian influenza "bird flu" (H5N1).

Design and Development of Enhanced Antimicrobial Breathable Biodegradable Polymeric Films for Food Packaging Applications.

The principle of breathable food packaging is to provide the optimal number of pores to transfer a sufficient amount of fresh air into the packaging headspace. In this work, antimicrobial microporous eco-friendly polymeric membranes were developed for food packaging. Polylactic acid (PLA) and polycaprolactone (PCL) were chosen as the main packaging polymers for their biodegradability.

Crystal structure of '-[2-(benzo[]thia-zol-2-yl)acet-yl]benzohydrazide, an achiral compound crystallizing in space group 1 with = 1.

In the mol-ecule of the title compound, CHNOS, one hydrazinic nitro-gen atom is essentially planar, but the other is slightly pyramidalized. The torsion angle about the hydrazinic bond is 66.44 (15)°.

Novel Synthesis and Antiviral Evaluation of New Benzothiazole-Bearing -Sulfonamide 2-Pyridone Derivatives as USP7 Enzyme Inhibitors.

In this article, a series of benzothiazole-bearing -sulfonamide 2-pyridone derivatives were synthesized via the reaction of benzothiazole sulfonylhydrazide with sodium salts of both (hydroxymethylene) cycloalkanones and unsaturated ketones, as well as ethoxymethylene derivatives. The structures of the resultant compounds were confirmed using IR, H NMR, C NMR, H-H correlation spectroscopy (COSY), H-C heteronuclear multiple bond coherence (HMBC), and H-C heteronuclear multiple quantum coherence (HSQC) spectral analysis and elemental analysis. The newly synthesized compounds were evaluated in vitro for their antiviral activities against the HSV-1, HAV HM175, HCVcc genotype 4, CBV4, and HAdV7 viruses.

Design and Synthesis of a New Class of Pyridine-Based -Sulfonamides Exhibiting Antiviral, Antimicrobial, and Enzyme Inhibition Characteristics.

A new strategy for designing and assembling a novel class of functionalized pyridine-based benzothiazole and benzimidazole incorporating sulfonamide moieties was developed. The synthesis was carried out by reacting -cyanoacetoarylsulfonylhydrazide with various electrophiles such as 2-(benzo[]thiazol-2-yl)-3,3-bis(alkylthio)acrylonitriles and 2-(benzo[]imidazol-2-yl)-3,3-bis(methylthio)-acrylonitriles, as well as 2-ethoxyl acrylonitrile derivatives. The synthesized compounds were tested for their antiviral and antimicrobial potency.

Tailored-design of electrospun nanofiber cellulose acetate/poly(lactic acid) dressing mats loaded with a newly synthesized sulfonamide analog exhibiting superior wound healing.

To effectively allow for controlled release of a newly synthesized sulfonamide analog, biodegradable poly(lactic acid) nanofibrous dressing mats tailored-designed for maximum wound healing efficacy were developed. The heterocyclic analog, N-(3,4-diamino-7-(benzo [d]thiazol-2-yl)-6-oxo-1H-pyrazolo[4,3-c]pyridin-5(6H)-yl)benzenesulfonamide, has been specifically synthesized to possess superior antibacterial and anti-inflammatory characteristics. Hydrophilic cellulose acetate and/or poly(ethylene oxide) were blended with the hydrophobic PLA to control the hydrophilicity/hydrophobicity ratio for the sustained release of the drug.

Design, Synthesis, and Antimicrobial Evaluation of a New Series of -Sulfonamide 2-Pyridones as Dual Inhibitors of DHPS and DHFR Enzymes.

Sulfonamides and trimethoprim (TMP) drugs are normally used to inhibit the action of dihydropteroate synthase (DHPS) and dihydrofolate reductase (DHFR) enzymes, respectively. In this work, a new series of -sulfonamide 2-pyridone derivatives that combine the inhibitory activities of DHPS and DHFR into one molecule were synthesized and evaluated for its antimicrobial activity and the ability to inhibit the action of both enzymes simultaneously. The synthesis was carried out via the reaction of novel benzothiazol sulfonylhydrazide with ketene dithioacetal derivatives, and the structures of the resultant compounds were confirmed using spectral and elemental techniques.

Efficient Synthesis and Docking Studies of Novel Benzothiazole-Based Pyrimidinesulfonamide Scaffolds as New Antiviral Agents and Hsp90α Inhibitors.

A series of novel substituted 2-pyrimidylbenzothiazoles incorporating either sulfonamide moieties or the amino group at C2 of the pyrimidine ring were synthesized and evaluated for its antiviral potency. The novel synthesis of the ring system was carried out by reacting guanidine or -arylsulfonated guanidine with different derivatives of ylidene benzothiazole based on Michael addition pathways. The antiviral activity of the newly synthesized compounds was examined by a plaque reduction assay against HSV-1, CBV4, HAV HM 175, HCVcc genotype 4 viruses, and HAdV7.

Crystal structure of potassium [4-amino-5-(benzo[]thia-zol-2-yl)-6-(methyl-sulfan-yl)pyrimidin-2-yl](phenyl-sulfon-yl)aza-nide di-methyl-formamide monosolvate hemihydrate.

The title compound, K·CHNOS ·CHNO·0.5HO, was obtained in a reaction designed to deliver a neutral 2-pyrimidylbenzo-thia-zole. The anion is deprotonated at the sulfonamide nitro-gen.

Imide-Based Polymers of Intrinsic Microporosity: Probing the Microstructure in Relation to CO Sorption Characteristics.

A range of microporous, imide-based polymers were newly synthesized using two-step poly-condensation reactions of bis(carboxylic anhydride) and various aromatic diamines for CO gas capture and storage applications. In this report, we attempted to assess the relative significance of molecular structural aspects through the manipulation of the conformational characteristics of the building blocks of the polymeric structures, the spiro-containing acid anhydride and the aromatic amines, to induce greater intrinsic microporosity and higher surface areas for the resulting solids. Results obtained from this study were thus used to outline a working relationship between the structural diversity of the constructed porous solids and their performance as CO sorbents.

Crystal structure of -[6-amino-5-(benzo[]thia-zol-2-yl)-3-cyano-4-methyl-sulfanyl-2-oxo-1,2-di-hydro-pyridin-1-yl]-4-methyl-benzene-sulfonamide di-methyl-formamide monosolvate.

In the title compound, CHNOS·CHNO, the toluene-sulfonamide ring and the combined ring system involving the pyridone and benzo-thia-zole rings subtend an inter-planar angle of 39.86 (4)°. The pyridone and benzo-thiazyl rings are linked by the intra-molecular hydrogen bond N-H⋯N.

Crystal structure of '-[2-(benzo[]thia-zol-2-yl)acet-yl]-4-methyl-benzene-sulfono-hydrazide.

In the title compound, CHNOS, the hydrazide N atom bonded to the C=O group is planar, whereas that bonded to the SO group is pyramidally coordinated. The inter-planar angle between the ring systems is 40.71 (3)°.

Crystal structure of 2-cyano-3,3-bis-(ethyl-sulfan-yl)---tolyl-acryl-amide.

In the mol-ecule of the title compound, CHNOS, the central SC=C(CN)C moiety is planar (r.m.s.

Multicomponent Reactions of Acetoacetanilide Derivatives with Aromatic Aldehydes and Cyanomethylene Reagents to Produce 4H-Pyran and 1,4-Dihydropyridine Derivatives with Antitumor Activities.

The multi-component reaction of either acetoacetanilide derivative 1a or b with any of the aldehyde derivatives 2a-d and malononitrile 3 in the presence of triethylamine as a catalyst gave the 4H-pyran derivatives 4a-g, respectively. Carrying the same reaction but using a catalytic amount of ammonium acetate gave the 1,4-dihydropyridine derivatives 5a-f, respectively. The use of ethyl cyanoacetate instead of malononitrile in the presence of a catalytic amount of triethylamine gave the 4H-pyran derivatives 7a-d, respectively.