Perylene diimide-based sensors for multiple analyte sensing (Fe/HS/ dopamine and Hg/Fe): cell imaging and INH, XOR, and encoder logic.

In this report, we present our results on the recognition of multiple analytes using trisubstituted PDI-based chemosensors DNP and DNB in 50% HEPES buffered-CHCN solution. Upon the addition of Hg, DNB showed a decrease and increase in absorbance intensity at 560 and 590 nm, respectively, with a detection limit of 7.17 μM and bleaching of the violet color (de-butynoxy).

Methanolic fraction of L. bark exhibits potential to combat oxidative stress and possess antiproliferative activity.

L. is well known for its traditional medicinal properties as an anti-inflammatory, hepatoprotective, antifungal, antibacterial, antimutagenic, and wound healing agent. The aim of the present study was to determine antioxidant, genoprotective, and cytotoxic potential of different fractions of bark including hexane (CaMH), chloroform (CaMC), ethyl acetate (CaME), and methanol (CaMM).

AIE+ESIPT Active Hydroxybenzothiazole for Intracellular Detection of Cu: Anticancer and Anticounterfeiting Applications.

Here, in the present work, a new hydroxybenzothiazole derivative () with AIE+ESIPT features was synthesized by Suzuki-Miyora coupling of with 4-formylphenylboronic acid. The AIE and ESIPT features were confirmed by optical, microscopic (AFM) and dynamic light scattering (DLS) techniques. The yellow fluorescent aggregates of can specifically detect Cu/Cu ions with limits of detection as low as 250 nM and 69 nM.

Mitochondria targeted dual-fluorescent probe for bio-imaging viscosity and F with different fluorescence signals.

The F ion and viscosity both affect the physiological state of mitochondria and to the best of our knowledge no fluorescent probe is reported for the dual detection of mitochondrial viscosity and F ion through different signals. DMAS-Si is weakly red fluorescent due to free intramolecular rotation between dimethylaminophenyl and pyridinium moieties and PET from silyloxy to the pyridinium moiety. In viscous medium (glycerol 90 %), the rotation is restricted and 18-fold increase in red-fluorescence (λ 637 nm) is observed.

Spray-Dried Microspheres of Carboplatin: Technology to Develop Longer-Acting Injectable with Improved Physio-Chemical Stability, Toxicity, and Therapeutics.

The present study aims to develop carboplatin injectable microspheres using spray-drying technology. The optimized powdered microspheres (MS-19-ST2) were morphologically spherical, with a 1.795 μm particle size and good micromeritic properties.