Publications by authors named "Raquel Vecino-Lopez"
Objectives: To study the health-related quality of life (HRQoL) and its possible determinant factors in Spanish children with eosinophilic esophagitis (EoE) and their parents.
Methods: Multicenter observational cross-sectional study. The Spanish version of the Pediatric Quality of Life Eosinophilic Esophagitis Module was filled out by EoE patients aged 8-18 and their parents.
Article Synopsis
- This study evaluated how effective proton pump inhibitors (PPIs) are for treating children with eosinophilic esophagitis (EoE) in both the short- and long-term, using a step-down therapy approach.
- Results showed that after initial treatment, over half of the children achieved significant histological and clinical remission, with normal endoscopic appearances linked to better outcomes, while those with fibrostenotic phenotypes averaged poorer responses.
- Long-term follow-up indicated that most children could maintain remission with reduced medication, and those starting with complete histological remission had a higher chance of sustained success; adverse effects were minimal.
Objectives: The objective of this study was to assess the association between serological markers and changes of the intestinal mucosa in children with celiac disease (CD).
Methods: Clinical data from CD patients under 15 years old were collected from the participating centers in an on-line multicenter nationwide observational Spanish registry called REPAC-2 (2011-2017). Correlation between anti-tissue transglutaminase antibodies (t-TGA) levels and other variables, including mucosal damage and clinical findings (symptoms, age, and gender), was assessed.
Background: Data regarding humoral and cellular response against SARS-CoV-2 in children are scarce. We analysed seroconversion rate, decrease of anti-RBD IgG antibodies over time and T-cell response in paediatric patients who suffered COVID-19.
Methods: Longitudinal study of paediatric patients COVID-19 diagnosed by positive molecular assay in nasopharyngeal swabs.
Objectives: Over the last several decades, there has been a tendency towards a predominance of less symptomatic forms of coeliac disease (CD) and an increase in the patient age at diagnosis. This study aimed to assess the clinical presentation and diagnostic process of paediatric CD in Spain.
Methods: A nationwide prospective, observational, multicentre registry of new paediatric CD cases was conducted from January 2011 to June 2017.
Article Synopsis
- A multicenter study involving 15 hospitals analyzed 101 pediatric patients hospitalized due to COVID-19, focusing on gastrointestinal (GI) symptoms.
- GI symptoms were found in 57% of the patients, with 14% experiencing them as the first sign of infection.
- Children with GI symptoms had an increased risk of requiring admission to the pediatric intensive care unit, indicating that these symptoms could predict the severity of COVID-19 in hospitalized kids.
Article Synopsis
- Exclusive enteral nutrition (EEN) is more effective than corticosteroids for achieving mucosal healing in children with Crohn's disease, without the negative side effects of steroids.
- A study covering 222 newly diagnosed pediatric patients found that 83% achieved clinical remission after an average of 8 weeks of EEN, with significant reductions in faecal calprotectin levels.
- Factors predicting a better response to EEN include specific scores on the Crohn's disease activity index, lower calprotectin levels, elevated CRP, and ileal involvement, suggesting EEN should be first-line treatment for pediatric Crohn's disease.
Objectives: The aim of the study was to describe diagnostic criteria used in children with coeliac disease (CD) and selective IgA deficiency; to determine if the publication of the 2012 ESPGHAN criteria prompted any changes; to evaluate the evolution of serological markers.
Methods: Multicenter, retrospective, descriptive study of a cohort of children under 15 years with selective IgA deficiency diagnosed with CD (January 2006 to December 2016). Demographic, clinical, genetic, histological and IgG-based antibodies were collected at diagnosis and follow-up.
A Multicenter, Prospective, Randomized Controlled Trial to Evaluate the Additional Benefit of a Multistrain Synbiotic (Prodefen®) in the Clinical Management of Acute Viral Diarrhea in Children.
Glob Pediatr Health
November 2016
This randomized, open-label study evaluated the additional benefits of the synbiotic Prodefen® in the clinical management of acute diarrhea of suspected viral origin in children between 6 months and 12 years of age. Study outcomes included the duration of diarrhea, the recovery from diarrhea, and the tolerability and acceptance of the treatment. The proportion of patients without diarrhea over the study period was greater in the synbiotic group than in the control group at all study time points, showing a statistically significant difference on the fifth day (95% vs 79%, p < 0.
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