Publications by authors named "Raquel V Portugal"
Background: Pegylated liposomal doxorubicin (PLD) is among the most active therapies for recurrent/progressive ovarian cancer (OC). Low-density lipoprotein receptor-related protein 1B (LRP1B) is one of the 10 most significantly deleted genes in human cancers. It mediates endocytosis of several factors from the cellular environment including liposomes.
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- * Low levels of E-cadherin and high levels of vimentin were linked to longer overall survival, while low expression of cytoplasmic OPN was also associated with better outcomes in platinum-resistant cases.
- * The study suggests that OPN expression, particularly nuclear and cytoplasmic forms, could serve as predictive markers for treatment responses, which may help guide clinical decisions in managing ovarian cancer patients.