Publications by authors named "Raquel Souza da Silva"
Development and Biocompatibility Assessment of Decellularized Porcine Uterine Extracellular Matrix-Derived Grafts.
Gustavo Henrique Doná Rodrigues Almeida Mariana Sversut Gibin Jaqueline de Carvalho Rinaldi Victória Hellen de Souza Gonzaga Camila Rodrigues Thom Raquel Souza da Silva
Tissue Eng Part C Methods
December 2024
Biomaterials derived from biological matrices have been widely investigated due to their great therapeutic potential in regenerative medicine, since they are able to induce cell proliferation, tissue remodeling, and angiogenesis . In this context, highly vascularized and proliferative tissues, such as the uterine wall, present an interesting source to produce acellular matrices that can be used as bioactive materials to induce tissue regeneration. Therefore, this study aimed to establish an optimized protocol to generate decellularized uterine scaffolds (dUT), characterizing their structural, compositional, and biomechanical properties.
View Article and Find Full Text PDFRegion-Specific Decellularization of Porcine Uterine Tube Extracellular Matrix: A New Approach for Reproductive Tissue-Engineering Applications.
Gustavo Henrique Doná Rodrigues Almeida Raquel Souza da Silva Mariana Sversut Gibin Victória Hellen de Souza Gonzaga Henrique Dos Santos
Biomimetics (Basel)
June 2024
Article Synopsis
- The study investigates the role of the extracellular matrix (ECM) in uterine tube physiology and aims to create region-specific decellularized scaffolds from porcine uterine tubes for tissue engineering applications.
- To achieve this, porcine uterine tubes were treated with specific solutions to remove cellular components while preserving the ECM structure and composition.
- Experimental results showed successful decellularization, maintaining the scaffold’s structural integrity, and high cell viability, indicating potential use in reproductive biotechnology.