Publications by authors named "Raquel M Carrera"
Article Synopsis
- COVID-19, caused by SARS-CoV-2, was declared a public health emergency in January 2020, with early studies showing that over 80% of deaths were among individuals aged 60 and older.
- The World Health Organization developed strategies to prioritize vaccine distribution, emphasizing the importance of vaccinating at-risk populations, particularly older adults, aiming for full vaccination coverage.
- Data analysis revealed that people aged 60 and above made up more than 80% of COVID-19 deaths globally, with significant mortality impact seen in lower and middle-income countries, highlighting the urgency for effective vaccine rollout.*
Zika virus (ZIKV) infection during pregnancy is associated with microcephaly, a congenital malformation resulting from neuroinflammation and direct effects of virus replication on the developing central nervous system (CNS). However, the exact changes in the affected CNS remain unknown. Here, we show by transcriptome analysis (at 48 h post-infection) and multiplex immune profiling that human induced-neuroprogenitor stem cells (hiNPCs) respond to ZIKV infection with a strong induction of type-I interferons (IFNs) and several type-I IFNs stimulated genes (ISGs), notably cytokines and the pro-apoptotic chemokines CXCL9 and CXCL10.
View Article and Find Full Text PDFBackground: Zika virus (ZIKV) was first identified in the Americas in 2015, when an outbreak of an exanthematous illness occurred in Brazil. Subsequentely, there was an increase of microcephaly cases, suggesting an association between ZIKV and this neurological complication. Currently, ZIKV has been recognised as causing a wide range of neurological complications including Guillain Barré syndrome, and myelitis.
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