Publications by authors named "Raquel Garcia Romero"
Infections caused by carbapenem-resistant Enterobacterales (CRE) are progressively increasing in Pediatric Intensive Care Units (PICUs). Its treatment is challenging due to the lack of pediatric trials. CRE infections are associated with significantly poor outcomes, but ceftazidime-avibactam (CAZ-AVI) has been reported to be successful in their treatment.
View Article and Find Full Text PDFPurpose: On the 14th of March 2020, the Spanish government decreed a state of alarm due to the coronavirus disease 2019 (COVID-19) pandemic, directly affecting healthcare. This situation led to delayed diagnosis of several serious diseases, and its impact on many diseases such as the onset of type 1 diabetes mellitus (T1DM) remains unknown. The aim of this study is to determine the impact of the COVID-19 pandemic on the onset of T1DM in children.
View Article and Find Full Text PDFArticle Synopsis
- - Current colorectal cancer (CRC) treatments often focus on DNA-damaging agents, but they don't work for all patients, and their effects on tumor behavior are not well understood.
- - Research using patient-derived organoids reveals that sublethal chemotherapy doses can make TP53 wildtype cancer cells enter a quiescent state, adopting a fetal-like phenotype that boosts their tumor-initiating and metastatic abilities.
- - The presence of this fetal phenotype and nuclear YAP1 in tumors at diagnosis is linked to poor patient outcomes, suggesting that combining chemotherapy with YAP1 inhibitors may improve treatment efficacy for resistant TP53 wildtype CRC cells.