Early detection of acute kidney injury through an alert system improves outcomes in hospitalized patients.

Background And Aims: Acute kidney injury (AKI) acquired in hospital settings has emerged as a significant public health issue. It is linked to prolonged hospital stays, increased healthcare costs, heightened risk of developing chronic kidney disease, mortality, and the need for ongoing post-hospitalization care. Our hypothesis suggests that timely recognition of AKI, identification of its underlying causes, and expert management by specialists could lead to improved prognoses for hospitalized patients.

Circulating myeloid-derived suppressor cells may be a useful biomarker in the follow-up of unvaccinated COVID-19 patients after hospitalization.

SARS-CoV-2 infection is the cause of the disease named COVID-19, a major public health challenge worldwide. Differences in the severity, complications and outcomes of the COVID-19 are intriguing and, patients with similar baseline clinical conditions may have very different evolution. Myeloid-derived suppressor cells (MDSCs) have been previously found to be recruited by the SARS-CoV-2 infection and may be a marker of clinical evolution in these patients.

Complete laboratory diagnosis of Insulin Autoimmune Syndrome.

The definition of Insulin autoimmune syndrome includes the presence of high levels of blood insulin and insulin autoantibodies. We encountered a 45-years-old white man with a high insulin serum value that do not fit with the C-peptide result. To discard or to confirm an analytical interference and diagnose a possible Insulin Autoimmune Syndrome we performed the following investigations: dilution linearity test, heterophilic antibody blocking, polyethylene glycol precipitation, measurements with alternative assays, and gel filtration chromatography by size exclusion.